Inhibition by acrolein of light-induced stomatal opening through inhibition of inward-rectifying potassium channels in <i>Arabidopsis thaliana</i>

Islam, Md. Moshiul; Ye, Wenxiu; Matsushima, Daiki; Khokon, Atiqur Rahman; Munemasa, Shintaro; Nakamura, Yoshimasa; Murata, Yoshiyuki

doi:10.1080/09168451.2014.951028

Cited by 10 publications

(5 citation statements)

References 27 publications

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“…Both methylglyoxal and 4-hydroxy-2-nonenal induce stomatal closure, and methylglyoxal additionally induces ROS production mediated by SHAM-sensitive peroxidases and [Ca 2+ ] cyt elevation (58,122). Moreover, carbonyl compounds such as methylglyoxal and acrolein inhibit K + in channels and light-induced stomatal opening (57,70). The reactive carbonyl compounds are likely to be closely involved in stomatal movements.…”

Section: Carbonyl Compoundsmentioning

confidence: 99%

Diverse Stomatal Signaling and the Signal Integration Mechanism

Murata

Mori

Munemasa

2015

Annu. Rev. Plant Biol.

296

235

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Guard cells perceive a variety of chemicals produced metabolically in response to abiotic and biotic stresses, integrate the signals into reactive oxygen species and calcium signatures, and convert these signatures into stomatal movements by regulating turgor pressure. Guard cell behaviors in response to such complex signals are critical for plant growth and sustenance in stressful, ever-changing environments. The key open question is how guard cells achieve the signal integration to optimize stomatal aperture. Abscisic acid is responsible for stomatal closure in plants in response to drought, and its signal transduction has been well studied. Other plant hormones and low-molecular-weight compounds function as inducers of stomatal closure and mediators of signaling in guard cells. In this review, we summarize recent advances in research on the diverse stomatal signaling pathways, with specific emphasis on signal integration and signal interaction in guard cell movement.

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Section: Carbonyl Compoundsmentioning

confidence: 99%

Diverse Stomatal Signaling and the Signal Integration Mechanism

Murata

Mori

Munemasa

2015

Annu. Rev. Plant Biol.

296

235

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“…While further detailed studies are needed to fully uncover the LRX-mediated PM H + -ATPase phosphorylation pathway, the uniqueness of AUs as stomatal opening inhibitors is obvious. The blue light-induced stomatal opening inhibitors discovered thus far are summarized in Figure . ,,,− ,− These inhibitors can be broadly divided into two categories: those targeting known receptor or mechanism (dashed line), and those discovered through phenotype-based chemical screening (double line). The former corresponds to inhibitors of mammalian homologues such as mammalian protein kinases inhibitor, whereas the latter mainly involves the discovery of first-in-class molecules.…”

Section: Discussionmentioning

confidence: 99%

Discovery of 2,6-Dihalopurines as Stomata Opening Inhibitors: Implication of an LRX-Mediated H⁺-ATPase Phosphorylation Pathway

et al. 2023

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Stomata are pores in the leaf epidermis of plants and their opening and closing regulate gas exchange and water transpiration. Stomatal movements play key roles in both plant growth and stress responses. In recent years, small molecules regulating stomatal movements have been used as a powerful tool in mechanistic studies, as well as key players for agricultural applications. Therefore, the development of new molecules regulating stomatal movement and the elucidation of their mechanisms have attracted much attention. We herein describe the discovery of 2,6-dihalopurines, AUs, as a new stomatal opening inhibitor, and their mechanistic study. Based on biological assays, AUs may involve in the pathway related with plasma membrane H + -ATPase phosphorylation. In addition, we identified leucine-rich repeat extensin proteins (LRXs), LRX3, LRX4 and LRX5 as well as RALF, as target protein candidates of AUs by affinity based pull down assay and molecular dynamics simulation. The mechanism of stomatal movement related with the LRXs−RALF is an unexplored pathway, and therefore further studies may lead to the discovery of new signaling pathways and regulatory factors in the stomatal movement.

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“…The blue light-induced stomatal opening inhibitors discovered thus far are summarized in Figure 9. 15,16,20,22,23,24,61,62,63 These inhibitors can be broadly divided into two categories: those targeting known receptor or mechanism (dashed line), and those discovered through phenotype-based chemical screening (double line). The former corresponds to inhibitors of mammalian homologues such as mammalian protein kinases inhibitor, whereas the latter mainly involves the discovery of first-in-class molecules.…”

Section: Discussionmentioning

confidence: 99%

Discovery of 2,6-Dihalopurines as Stomata Opening Inhibitors: Implication of an LRX-mediated H+-ATPase Phosphorylation Pathway

Itami

Ueda

Aihara

et al. 2022

Preprint

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Stomata are pores in the leaf epidermis of plants and their opening and closing regulate gas exchange and water transpiration. Stomatal movements play key roles in both plant growth and stress responses. In recent years, small molecules regulating stomatal movements have been used as a powerful tool in mechanistic studies, as well as key players for agricultural applications. Therefore, the development of new molecules regulating stomatal movement and the elucidation of their mechanisms have attracted much attention. We herein describe the discovery of 2,6-dihalopurines, AUs, as a new stomatal opening inhibitor, and their mechanistic study. Based on biological assays, AUs may involve in the pathway related with plasma membrane H+-ATPase phosphorylation. In addition, we identified leucine-rich repeat extensin proteins (LRXs), LRX3, LRX4 and LRX5 as well as RALF, as target protein candidates of AUs by affinity based pull down assay and molecular dynamics simulation. The mechanism of stomatal movement related with the LRXs–RALF is an unexplored pathway, and therefore further studies may lead to the discovery of new signaling pathways and regulatory factors in the stomatal movement.

show abstract

Inhibition by acrolein of light-induced stomatal opening through inhibition of inward-rectifying potassium channels in Arabidopsis thaliana

Cited by 10 publications

References 27 publications

Diverse Stomatal Signaling and the Signal Integration Mechanism

Diverse Stomatal Signaling and the Signal Integration Mechanism

Discovery of 2,6-Dihalopurines as Stomata Opening Inhibitors: Implication of an LRX-Mediated H⁺-ATPase Phosphorylation Pathway

Discovery of 2,6-Dihalopurines as Stomata Opening Inhibitors: Implication of an LRX-mediated H+-ATPase Phosphorylation Pathway

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Inhibition by acrolein of light-induced stomatal opening through inhibition of inward-rectifying potassium channels in Arabidopsis thaliana

Cited by 10 publications

References 27 publications

Diverse Stomatal Signaling and the Signal Integration Mechanism

Diverse Stomatal Signaling and the Signal Integration Mechanism

Discovery of 2,6-Dihalopurines as Stomata Opening Inhibitors: Implication of an LRX-Mediated H+-ATPase Phosphorylation Pathway

Discovery of 2,6-Dihalopurines as Stomata Opening Inhibitors: Implication of an LRX-mediated H+-ATPase Phosphorylation Pathway

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Discovery of 2,6-Dihalopurines as Stomata Opening Inhibitors: Implication of an LRX-Mediated H⁺-ATPase Phosphorylation Pathway