Inhibition by capsaicin against cyclophosphamide-induced clastogenicity and DNA damage in mice

De, Amit Krishna; Agarwal, Kalpana; Mukherjee, Anita; Sengupta, Debmalya

doi:10.1016/0165-1161(95)00028-3

Cited by 23 publications

(8 citation statements)

References 13 publications

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“…Salvadori et al [30] found radioprotective effects of β-carotene in splenocytes, reticulocytes, and spermatids, but not in bone marrow of mice. Also, some chemicals possess abilities to reduce the mutagenic effects caused by other chemicals [31][32][33][34][35]. A few articles describe synergy or exacerbation of response after combined treatment [36][37][38][39].…”

Section: Discussionmentioning

confidence: 99%

Induction of micronuclei in bone marrow and sperm head abnormalities after combined exposure of mice to low doses of X-rays and acrylamide

Dobrzyńska¹,

Gajewski²

2000

Teratog. Carcinog. Mutagen.

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Section: Discussionmentioning

confidence: 99%

Induction of micronuclei in bone marrow and sperm head abnormalities after combined exposure of mice to low doses of X-rays and acrylamide

Dobrzyńska¹,

Gajewski²

2000

Teratog. Carcinog. Mutagen.

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“…Arceo et al [1995] discovered small but statistically significant increases in the incidence of micronucleated mature peripheral blood erythrocytes and in sister chromatid exchanges (SCEs) in bone marrow cells following daily intraperitoneal injections of capsaicin at a maximum level of 1.9 mg/kg/day. In comparison, De et al [1995] found that pretreatment with capsaicin by intraperitoneal injection protected against the clastogenic and DNA-damaging effects of cyclophosphamide in mouse bone marrow cells.…”

Section: Introductionmentioning

confidence: 96%

Examination of the potential genotoxicity of pure capsaicin in bacterial mutation, chromosome aberration, and rodent micronucleus tests

Proudlock¹,

Thompson²,

Longstaff³

2004

Environ and Mol Mutagen

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There is widespread dietary exposure to capsaicin in the form of chili peppers, while capsaicin's analgesic qualities have led to increased use of a topical herbal remedy in various impure forms. Most recently, injection of pure capsaicin has been proposed as a means of relieving a variety of debilitating diseases, in which case tissues would receive relatively high and direct exposure. The purpose of the present study, where a series of standard assays were performed in accordance with the Organisation for Economic Cooperation and Development guidance, was to clarify earlier conflicting reports concerning potential genotoxicity of capsaicin prior to administering it to patients in an injectable form. The results confirm the absence of genotoxic activity of high-purity capsaicin in the bacterial mutation and chromosome aberration tests. In addition, no evidence of cytotoxicity or genotoxicity was seen in the rat bone marrow micronucleus test, where systemic exposure to pure capsaicin was achieved using the subcutaneous route and a rising dose toleration protocol. It is concluded that pure capsaicin is not active in the standard battery of genotoxicity assays recommended by the International Conference on Harmonisation for evaluation of new medicines; earlier reported in vitro genotoxic activity is probably associated with mutagenic impurities in commercial grades of the material.

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“…Earlier, Villaseñor et al (1993) had also shown that capsaicin at a maximum tolerable dose of 1.22 mg/kg (intraperitoneally) was not mutagenic in the same assay. In another study, De et al (1995) showed that capsaicin significantly inhibited cyclophosphamide-induced chromosomal aberrations and DNA strand breakages in bone marrow cells of Swiss albino mice. These groups concluded that capsaicin was non-clastogenic.…”

Section: In Vivo Genotoxicitymentioning

confidence: 99%

A Comprehensive Review of the Carcinogenic and Anticarcinogenic Potential of Capsaicin

et al. 2012

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Human exposure to capsaicin, the most abundant pungent chili pepper component, is ubiquitous. Evaluation of capsaicin's carcinogenic potential has produced variable results in in vitro and in vivo genotoxicity and carcinogenicity assays. The capsaicin tested in older studies was often from pepper plant extracts and included other capsaicinoids and diverse impurities. Recent studies utilizing high-purity capsaicin and standardized protocols provide evidence that the genotoxic and carcinogenic potential of capsaicin is quite low and that the purity of capsaicin is important. Several small epidemiological studies suggest a link between capsaicin consumption and stomach or gall bladder cancer, but contamination of capsaicin-containing foods with known carcinogens renders their interpretation problematic. The postulated ability of capsaicin metabolites to damage DNA and promote carcinogenesis remains unsupported. Anticancer activities of capsaicin have been widely reported, as it inhibits the activity of carcinogens and induces apoptosis in numerous cancer cell lines in vitro and explanted into rodents. Diverse mechanisms have been postulated for capsaicin's anticancer properties. One hypothesis is that inhibition of cytochrome P450 enzymes-particularly CYP2E1-retards carcinogen activation but is contradicted by the low potency of capsaicin for CYP inhibition. The potential for dietary capsaicin to act as a chemopreventative is now widely postulated.

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Inhibition by capsaicin against cyclophosphamide-induced clastogenicity and DNA damage in mice

Cited by 23 publications

References 13 publications

Induction of micronuclei in bone marrow and sperm head abnormalities after combined exposure of mice to low doses of X-rays and acrylamide

Induction of micronuclei in bone marrow and sperm head abnormalities after combined exposure of mice to low doses of X-rays and acrylamide

Examination of the potential genotoxicity of pure capsaicin in bacterial mutation, chromosome aberration, and rodent micronucleus tests

A Comprehensive Review of the Carcinogenic and Anticarcinogenic Potential of Capsaicin

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