Inhibition by H-1 virus of the incidence of tumors produced by adenovirus 12 in hamsters

Some Antigenic Relationships of the Murine Parvoviruses: Minute Virus of Mice, Rat Virus, and H-1 Virus

“…Antibody to MVM has been found to be prevalent in rat sera, but the evidence that the antibody resulted from MVM infection is not conclusive; however, the data are considered as evidence that rats are natural hosts for MVM or a related agent (5,12). 11-1 virus isolations have been reported from human tumor materials ( 3 ) and human embryos (17) ; and HI and neutralizing antibody had occasionally been detected in human sera (18,19). The credibility of the data, however, has been questioned (18)(19)(20), and in more recent studies investigators were unable to detect antibody or isolate virus from similar materials ( 2 0 ) .…”

Translationally controlled tumor protein is a target of tumor reversion

“…To obtain these revertants, we used the approach as described (1,2,4): the tumor cells were infected with H1 parvovirus that kills preferentially the malignant cells (20,21), while sparing their normal counterparts and cells that are resistant to the cytopathic effect of the virus. Resistant clones were isolated, and their phenotype was assessed by measuring anchorage dependence in a soft agar assay (Fig.…”

Translation Control by Protein Kinase R Restricts Minute Virus of Mice Infection: Role in Parvovirus Oncolysis

“…The MVM prototype strain, MVMp, is apathogenic for newborn and adult mice (10) but infects and kills certain human tumor cell lines in vitro (49,62). The parvoviral oncosuppressive phenomenon has been extensively evaluated with regard to infection of fibroblasts, epithelial cells (reviewed in reference 62), and neural cells (63) transformed by a wide variety of agents (16,49) as well as in animal models of human cancer (1,25,77). The molecular mechanisms regulating autonomous parvovirus infection of normal and neoplastic cells operate at the recognition of cell surface receptors (55) as well as at multiple intracellular interactions which are only partially understood.…”