Inhibition by Somatostatin of Secretin-Stimulated Pancreatic Secretion in Man: A Study with Pure Pancreatic Juice

Domschke, S; Domschke, Wolfram; Rösch, Wolfgang; Konturek, S J; Sprügel, W.; Mitznegg, P; Wünsch, Erich; Demling, L

doi:10.1080/00365521.1977.12031112

Cited by 60 publications

(12 citation statements)

References 13 publications

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“…The pancreatic duct does not absorb the Na + , but absorbs most of the Cl − and secret HCO 3 − . The human pancreatic duct can secrete a fluid containing 140 mM HCO 3 − (86). However, the HCO 3 − concentration in mouse and rat pancreatic juice is 50–70 mM (386).…”

Section: General Considerationsmentioning

confidence: 99%

“…Several bodily fluids have higher HCO 3 − concentration, and among them the pancreatic juice contains the highest concentration. In humans and several other species, such as dogs, cats, and guinea pigs, HCO 3 − concentration in the juice secreted by the stimulated pancreas can be higher than 140 mM (86, 237). This remarkable transport feat attracts considerable attention to pancreatic HCO 3 − secretory mechanism, which is the model of choice to gain insight into the mechanism of epithelial fluid and HCO 3 − transport.…”

Section: Introductionmentioning

confidence: 99%

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Molecular Mechanism of Pancreatic and Salivary Gland Fluid and HCO₃⁻Secretion

Lee

Ohana

Park

et al. 2012

Physiological Reviews

349

455

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Fluid and HCO3−secretion is a vital function of all epithelia and is required for the survival of the tissue. Aberrant fluid and HCO3−secretion is associated with many epithelial diseases, such as cystic fibrosis, pancreatitis, Sjögren's syndrome, and other epithelial inflammatory and autoimmune diseases. Significant progress has been made over the last 20 years in our understanding of epithelial fluid and HCO3−secretion, in particular by secretory glands. Fluid and HCO3−secretion by secretory glands is a two-step process. Acinar cells secrete isotonic fluid in which the major salt is NaCl. Subsequently, the duct modifies the volume and electrolyte composition of the fluid to absorb the Cl−and secrete HCO3−. The relative volume secreted by acinar and duct cells and modification of electrolyte composition of the secreted fluids varies among secretory glands to meet their physiological functions. In the pancreas, acinar cells secrete a small amount of NaCl-rich fluid, while the duct absorbs the Cl−and secretes HCO3−and the bulk of the fluid in the pancreatic juice. Fluid secretion appears to be driven by active HCO3−secretion. In the salivary glands, acinar cells secrete the bulk of the fluid in the saliva that is driven by active Cl−secretion and contains high concentrations of Na+and Cl−. The salivary glands duct absorbs both the Na+and Cl−and secretes K+and HCO3−. In this review, we focus on the molecular mechanism of fluid and HCO3−secretion by the pancreas and salivary glands, to highlight the similarities of the fundamental mechanisms of acinar and duct cell functions, and to point out the differences to meet gland-specific secretions.

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Section: General Considerationsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Molecular Mechanism of Pancreatic and Salivary Gland Fluid and HCO₃⁻Secretion

Lee

Ohana

Park

et al. 2012

Physiological Reviews

349

455

View full text Add to dashboard Cite

show abstract

“…This process has been demonstrated in various tissues after SP administration (Sheppard et al 1979), including in the pancreas (Sakamoto et al 1984). Somatostatin is known to inhibit secretin-, cholecystokinin-and meal-stimulated pancreatic secretion in dogs and man (Konturek et al 1976;Domschke et al 1977;Susini et al 1978).…”

Section: Discussionmentioning

confidence: 95%

Effects of Substance P on Pancreatic Exocrine Secretion Stimulated by Secretin, Dopamine and Cholecystokinin in Dogs

Iwatsuki

Yamagishi

Chiba

1986

Clin Exp Pharma Physio

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The effect of substance P (SP) on pancreatic exocrine responses to exogenous cholecystokinin, secretin, and dopamine, were studied in the isolated and blood-perfused pancreas of dogs. Intra-arterial injection of SP had a significant biphasic effect on pancreatic secretion: an initial transient inhibition, followed by an increase in the secretion stimulated by the infusion of cholecystokinin. However, SP caused only an inhibition of secretion stimulated by the infusion of secretin and dopamine. SP increased protein concentration but not bicarbonate concentration in juice stimulated by cholecystokinin, but SP did not affect significantly either protein or bicarbonate concentrations in juice stimulated by secretin and dopamine. These results suggest that SP has greater effects on the pancreatic secretion stimulated by cholecystokinin than that stimulated by secretin and dopamine.

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“…The human exocrine pancreas secretes 1-2 liters of pancreatic juice per day. When stimulated, the pancreas secretes alkaline pancreatic juice containing copious amounts of bicarbonate (HCO 3 -) (23,74). HCO 3 plays essential roles in the digestive system.…”

Section: Introductionmentioning

confidence: 99%

“…According to the Henderson-Hasselbalch equation, at pH 7.4 and 5% CO 2 , the HCO 3 equilibrium concentration in plasma is approximately 25 mM. In humans, dogs, cats, and guinea pigs, HCO 3 concentration in postprandial pancreatic juice is higher than 140 mM (23,74). This remarkable transport performance has attracted much attention from pancreatologists and physiologists.…”

Section: Introductionmentioning

confidence: 99%

Molecular Mechanisms of Pancreatic Bicarbonate Secretion

Lee¹,

Kim²,

Jun³

et al.

Pancreapedia: Exocrine Pancreas Knowledge Base

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Inhibition by Somatostatin of Secretin-Stimulated Pancreatic Secretion in Man: A Study with Pure Pancreatic Juice

Cited by 60 publications

References 13 publications

Molecular Mechanism of Pancreatic and Salivary Gland Fluid and HCO₃⁻Secretion

Molecular Mechanism of Pancreatic and Salivary Gland Fluid and HCO₃⁻Secretion

Effects of Substance P on Pancreatic Exocrine Secretion Stimulated by Secretin, Dopamine and Cholecystokinin in Dogs

Molecular Mechanisms of Pancreatic Bicarbonate Secretion

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Inhibition by Somatostatin of Secretin-Stimulated Pancreatic Secretion in Man: A Study with Pure Pancreatic Juice

Cited by 60 publications

References 13 publications

Molecular Mechanism of Pancreatic and Salivary Gland Fluid and HCO3−Secretion

Molecular Mechanism of Pancreatic and Salivary Gland Fluid and HCO3−Secretion

Effects of Substance P on Pancreatic Exocrine Secretion Stimulated by Secretin, Dopamine and Cholecystokinin in Dogs

Molecular Mechanisms of Pancreatic Bicarbonate Secretion

Contact Info

Product

Resources

About

Molecular Mechanism of Pancreatic and Salivary Gland Fluid and HCO₃⁻Secretion

Molecular Mechanism of Pancreatic and Salivary Gland Fluid and HCO₃⁻Secretion