Inhibition in the somatosensory system: An integrative neuropharmacological and neuroimaging approach

C, Fioravanti; Kajal, Diljit Singh; Carboni, Margherita; Mazzetti, C.; Ziemann, Ulf; Braun, Christoph

doi:10.1016/j.neuroimage.2019.116139

Cited by 6 publications

(3 citation statements)

References 46 publications

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“…Cortical beta coherence during balance reactions in older adults may reveal important information about the role of age-related cortical inhibitory processes (Peiffer et al, 2007;Zwergal et al, 2012). Movement-related beta oscillations have been associated with inhibitory GABAergic network activity (Baker, 2007;Muthukumaraswamy et al, 2013), which plays a central role in the modulation of somatosensory processing (Fioravanti et al, 2019). GABAergic networks can precisely influence corticomotor output through synaptic connections with pyramidal neurons, fine-tuning motor control processes (Yamawaki et al, 2008).…”

Section: Role Of Cortical Inhibitory Processes In Balance Control Witmentioning

confidence: 99%

Prefrontal-motor and somatosensory-motor cortical network interactions during reactive balance are associated with distinct aspects of balance behavior in older adults

Palmer

Payne

Ting

et al. 2021

Preprint

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Heightened reliance on the cerebral cortex for postural stability with aging is well-known, yet the cortical dynamics of balance control, particularly in relationship to balance function, is unclear. Here we aimed to investigate motor cortical activity in relationship to the level of balance challenge presented during reactive balance recovery, and identify circuit-specific interactions between motor cortex and prefrontal or somatosensory regions to metrics of balance function that predict fall risk. Using electroencephalography, we assessed motor cortical beta power, and beta coherence during balance reactions to perturbations in older adults. We found that individuals with greater somatosensory-motor beta coherence at baseline and lower beta power evoked over motor regions following perturbations demonstrated higher general clinical balance function. At the group-level, beta coherence between prefrontal-motor regions reduced during balance reactions. Older adults with the highest post-perturbation prefrontal-motor coherence showed greater cognitive dual-task interference and elicited stepping reactions at lower perturbation magnitudes. Our results support motor cortical beta activity as a potential biomarker for individual level of balance challenge and implicate prefrontal-and somatosensory-motor cortical networks in different aspects of balance control in older adults. Cortical network activity during balance may provide a neural target for precision-medicine efforts aimed at fall-prevention with aging.

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Section: Role Of Cortical Inhibitory Processes In Balance Control Witmentioning

confidence: 99%

Prefrontal-motor and somatosensory-motor cortical network interactions during reactive balance are associated with distinct aspects of balance behavior in older adults

Palmer

Payne

Ting

et al. 2021

Preprint

View full text Add to dashboard Cite

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“…Movement-related beta oscillations have been associated with GABAergic network activity [27,28] with primary anatomical origins within thalamocortical sensorimotor networks, including the primary motor cortex [71][72][73]. GABAergic networks play a central role in the modulation of somatosensory processing [74] and can influence corticomotor output through inhibitory and reciprocal connections with pyramidal cells [75]. A relationship between beta oscillations and somatosensory processing is also supported by larger somatosensory-evoked potential amplitudes when evoked during spontaneous phasic increases in beta power [76].…”

Section: Role Of Sensorimotor Cortical Processing In Standing Balance Controlmentioning

confidence: 99%

Cortical Beta Oscillatory Activity Evoked during Reactive Balance Recovery Scales with Perturbation Difficulty and Individual Balance Ability

et al. 2020

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Cortical beta oscillations (13–30 Hz) reflect sensorimotor processing, but are not well understood in balance recovery. We hypothesized that sensorimotor cortical activity would increase under challenging balance conditions. We predicted greater beta power when balance was challenged, either by more difficult perturbations or by lower balance ability. In 19 young adults, we measured beta power over motor cortical areas (electroencephalography, Cz electrode) during three magnitudes of backward support -surface translations. Peak beta power was measured during early (50–150 ms), late (150–250 ms), and overall (0–400 ms) time bins, and wavelet-based analyses quantified the time course of evoked beta power. An ANOVA was used to compare peak beta power across perturbation magnitudes in each time bin. We further tested the association between perturbation-evoked beta power and individual balance ability measured in a challenging beam walking task. Beta power increased ~50 ms after perturbation, and to a greater extent in larger perturbations. Lower individual balance ability was associated with greater beta power in only the late (150–250 ms) time bin. These findings demonstrate greater sensorimotor cortical engagement under more challenging balance conditions, which may provide a biomarker for reduced automaticity in balance control that could be used in populations with neurological impairments.

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“…Movement-related beta oscillations have been associated with GABAergic network activity (Baker, 2007;Muthukumaraswamy et al, 2013) with primary anatomical origins within thalamocortical sensorimotor networks, including the primary motor cortex Jurkiewicz et al, 2006;Salmelin et al, 1995). GABAergic networks play a central role in the modulation of somatosensory processing (Fioravanti et al, 2019) and can influence corticomotor output through inhibitory and reciprocal connections with pyramidal cells (Yamawaki et al, 2008). A relationship between beta oscillations and somatosensory processing is also supported by larger somatosensory-evoked potential amplitudes when evoked during spontaneous phasic increases in beta power (Lalo et al, 2007).…”

Section: Role Of Sensorimotor Cortical Processing In Standing Balancementioning

confidence: 99%

Cortical beta oscillatory activity evoked during reactive balance recovery scales with perturbation difficulty and individual balance ability

Ghosn

Palmer

Borich

et al. 2020

Preprint

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I.AbstractCortical beta oscillations (13-30 Hz) reflect sensorimotor cortical activity, but have not been fully investigated in balance recovery behavior. We hypothesized that more challenging balance conditions would lead to greater recruitment of cortical sensorimotor brain regions for balance recovery. We predicted that beta power would be enhanced when balance recovery is more challenging, either due to more difficult perturbations or due to lower intrinsic balance ability. In 19 young adults, we measured beta power evoked over motor cortical areas (Cz electrode) during 3 magnitudes of backward support-surface translational perturbations using electroencephalography. Peak beta power was measured during early (50-150 ms), late (150-250 ms), and overall (0-400 ms) time bins, and wavelet-based analyses quantified the time course of evoked beta power and agonist and antagonist ankle muscle activity. We further assessed the relationship between individual balance ability measured in a challenging beam walking task and perturbation-evoked beta power within each time bin. In balance perturbations, cortical beta power increased ∼50 ms after perturbation onset, demonstrating greater increases with increasing perturbation magnitude. Balance ability was negatively associated with peak beta power in only the late (150-250 ms) time bin, with higher beta power in individuals who performed worse in the beam walking task. Additionally, the time course of cortical beta power followed a similar waveform as the evoked muscle activity, suggesting these evoked responses may be initially evoked by shared underlying mechanisms. These findings support the active role of sensorimotor cortex in balance recovery behavior, with greater recruitment of cortical resources under more challenging balance conditions. Cortical beta power may therefore provide a biomarker for engagement of sensorimotor cortical resources during reactive balance recovery and reflect the individual level of balance challenge.

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Inhibition in the somatosensory system: An integrative neuropharmacological and neuroimaging approach

Cited by 6 publications

References 46 publications

Prefrontal-motor and somatosensory-motor cortical network interactions during reactive balance are associated with distinct aspects of balance behavior in older adults

Prefrontal-motor and somatosensory-motor cortical network interactions during reactive balance are associated with distinct aspects of balance behavior in older adults

Cortical Beta Oscillatory Activity Evoked during Reactive Balance Recovery Scales with Perturbation Difficulty and Individual Balance Ability

Cortical beta oscillatory activity evoked during reactive balance recovery scales with perturbation difficulty and individual balance ability

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