2024
DOI: 10.1186/s10194-024-01817-z
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Inhibition of 2-AG hydrolysis alleviates posttraumatic headache attributed to mild traumatic brain injury

Jie Wen,
Mikiei Tanaka,
Yumin Zhang

Abstract: Background Posttraumatic headache (PTH) is a common and debilitating symptom following repetitive mild traumatic brain injury (rmTBI), and it mainly resembles a migraine-like phenotype. While modulation of the endocannabinoid system (ECS) is effective in treating TBI and various types of pain including migraine, the role of augmentation of endocannabinoids in treating PTH has not been investigated. Methods Repetitive mild TBI was induced in male C5… Show more

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Cited by 2 publications
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