2020
DOI: 10.4081/ejtm.2019.8737
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Inhibition of Activin/Myostatin signalling induces skeletal muscle hypertrophy but impairs mouse testicular development

Abstract: Numerous approaches are being developed to promote post-natal muscle growth based on attenuating Myostatin/Activin signalling for clinical uses such as the treatment neuromuscular diseases, cancer cachexia and sarcopenia. However there have been concerns about the effects of inhibiting Activin on tissues other than skeletal muscle. We intraperitoneally injected mice with the Activin ligand trap, sActRIIB, in young, adult and a progeric mouse model. Treatment at any stage in the life of the mouse rapidly increa… Show more

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Cited by 9 publications
(10 citation statements)
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“…Here we examine the molecular basis underpinning the impact of sActRIIB on the testis (Vaughan et al, 2020b).…”
Section: Discussionmentioning
confidence: 99%
See 3 more Smart Citations
“…Here we examine the molecular basis underpinning the impact of sActRIIB on the testis (Vaughan et al, 2020b).…”
Section: Discussionmentioning
confidence: 99%
“…However, we and others have documented that these interventions can also result in unwanted side effects ( Campbell et al, 2017 ). In particular, we have focused, in a number of studies, on the detrimental effect of sActRIIB on testis development that accompanies muscle growth ( Vaughan et al, 2020a , b ). Here, we examine the molecular basis underpinning the impact of sActRIIB on the testis.…”
Section: Discussionmentioning
confidence: 99%
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“…Likewise, recent studies have reported differences in protein metabolism in short-term muscle disuse [ 47 ] compared to cancer cachexia [ 24 ]. Unfortunately, due to the pleiotropic effects of myostatin, targeting this myokine is not a straightforward approach [ 48 ].…”
Section: Use and Misuse Of The Term “Cachexia” In Fasting Muscle mentioning
confidence: 99%