Inhibition of adherence of corynebacterium diphtheriae to human buccal epitelium by glycoside hydrolases of marine hydrobiontes

Ts, Zaporozhets; Макаренкова, И. Д.; IIu, Bakunina; IuV, Burtseva; Mi, Kusaĭkin; La, Balabanova; Tn, Zviagintseva; Nn, Besednova; Va, Rasskazov

doi:10.18097/pbmc20105603350

Cited by 3 publications

(1 citation statement)

References 13 publications

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“…Although this result supports previous findings that mannan is the most important C. albicans adhering glycan [56] and that loss of phosphomannan correlates with reduced levels of the AMP dermaseptin S3 bound to the cells [57] , it also raises the possibility that LL-37 interferes with C. albicans cell-wall remodeling. It is thought that some proteins with enzymatic activity on the C. albicans cell surface could be bound by LL-37, leading to dysfunction of carbohydrate metabolism [58] , impairment of cell-wall construction, and prevention of C. albicans /host adhesion. C. albicans cell-wall remodeling occurs during infection and drug (e.g., caspofungin) treatment, and consequently the inner glucan layer is exposed during remodeling [59] , [60] .…”

Section: Discussionmentioning

confidence: 99%

Human Antimicrobial Peptide LL-37 Inhibits Adhesion of Candida albicans by Interacting with Yeast Cell-Wall Carbohydrates

et al. 2011

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Candida albicans is the major fungal pathogen of humans. Fungal adhesion to host cells is the first step of mucosal infiltration. Antimicrobial peptides play important roles in the initial mucosal defense against C. albicans infection. LL-37 is the only member of the human cathelicidin family of antimicrobial peptides and is commonly expressed in various tissues and cells, including epithelial cells of both the oral cavity and urogenital tract. We found that, at sufficiently low concentrations that do not kill the fungus, LL-37 was still able to reduce C. albicans infectivity by inhibiting C. albicans adhesion to plastic surfaces, oral epidermoid OECM-1 cells, and urinary bladders of female BALB/c mice. Moreover, LL-37-treated C. albicans floating cells that did not adhere to the underlying substratum aggregated as a consequence of LL-37 bound to the cell surfaces. According to the results of a competition assay, the inhibitory effects of LL-37 on cell adhesion and aggregation were mediated by its preferential binding to mannan, the main component of the C. albicans cell wall, and partially by its ability to bind chitin or glucan, which underlie the mannan layer. Therefore, targeting of cell-wall carbohydrates by LL-37 provides a new strategy to prevent C. albicans infection, and LL-37 is a useful, new tool to screen for other C. albicans components involved in adhesion.

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Section: Discussionmentioning

confidence: 99%

Human Antimicrobial Peptide LL-37 Inhibits Adhesion of Candida albicans by Interacting with Yeast Cell-Wall Carbohydrates

et al. 2011

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Suppression of Bacterial Adhesion: Modern Approaches, Problems, and Prospects

2020

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Antibiofilm Activity of Fukoidans Isolated from Brown Algae

Matosova,

Besednova,

Kusaikin

et al. 2024

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Biofilms play a significant role in the existence of bacteria under adverse conditions and the pathogenesis of infections. They contribute to the creation of reservoirs of antibiotic-resistant pathogens. This determines the relevance of the search for biologically active substances that inhibit the formation of biofilms. In recent years, the objects of intensive study are fucoidans — sulfated polysaccharides from marine brown algae, which have a wide polyfunctional spectrum of action. Their influence on the formation of Yersinia pseudotuberculosis biofilm in a dynamic model simulating the natural conditions of ecosystems of fucoidans belonging to different structural groups was investigated in this study. They are synthesized by brown algae: Fucus evanescens, Saccharina cichorioides, and Saccharina japonica. The fucoidan isolated from F.evanescens have showed the most pronounced antibiotic activity. The authors developed a new approach that allows obtaining stable results of multidirectional action of sulfated polysaccharides on the biofilm formation of Y.pseudotuberculosis.

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Inhibition of adherence of corynebacterium diphtheriae to human buccal epitelium by glycoside hydrolases of marine hydrobiontes

Cited by 3 publications

References 13 publications

Human Antimicrobial Peptide LL-37 Inhibits Adhesion of Candida albicans by Interacting with Yeast Cell-Wall Carbohydrates

Human Antimicrobial Peptide LL-37 Inhibits Adhesion of Candida albicans by Interacting with Yeast Cell-Wall Carbohydrates

Suppression of Bacterial Adhesion: Modern Approaches, Problems, and Prospects

Antibiofilm Activity of Fukoidans Isolated from Brown Algae

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