Inhibition of Advanced Glycation Endproduct Formation by Lotus Seedpod Oligomeric Procyanidins through RAGE–MAPK Signaling and NF-κB Activation in High-Fat-Diet Rats

Wu, Qian; Li, Shuyi; Li, Xiaopeng; Sui, Yong; Yang, Yan; Dong, Lihong; Xie, Bijun; Sun, Zhida

doi:10.1021/acs.jafc.5b01082

Cited by 46 publications

(33 citation statements)

References 45 publications

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“…Thus, it is not surprising that a heat‐processed diet high in AGEs may contain lower amounts of heat‐sensitive bioactives, which has been evidenced by an earlier interventional study, where the level of Vc in the high‐AGE diet was 30% lower than that in the steamed diet (Birlouez‐Aragon et al., 2010). In this context, some of the natural compounds have shown beneficial effects toward AGE‐mediated pathogenesis both in vitro and in vivo , such as quercetin (Li, Zheng, Sang, & Lv, 2014) and procyanidin (Wu et al., 2015). Therefore, it is reasonable to believe that the deficiency of heat‐sensitive nutrients might, to some extent, contribute to the detrimental effects of high‐AGE foods.…”

Section: Health Implications Of Dages: Perspectives To Fill the Gap Bmentioning

confidence: 99%

Dietary advanced glycation end‐products: Perspectives linking food processing with health implications

Zhang

2020

Comp Rev Food Sci Food Safe

144

116

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Dietary advanced glycation end products (dAGEs) are complex and heterogeneous compounds derived from nonenzymatic glycation reactions during industrial processing and home cooking. There is mounting evidence showing that dAGEs are closely associated with various chronic diseases, where the absorbed dAGEs fuel the biological AGEs pool to exhibit noxious effects on human health. Currently, due to the uncertain bioavailability and rapid renal clearance of dAGEs, the relationship between dAGEs and biological AGEs remains debatable. In this review, we provide the most updated information on dAGEs including their generation in processed foods, analytical and characterization techniques, metabolic fates, interaction with AGE receptors, implications on human health and reducing strategies. Available evidence demonstrating a relevance between dAGEs and food allergy is also included. AGEs are ubiquitous in foods and their contents largely depend on the reactivity of carbonyl and amino groups, along with surrounding condition mainly pH and heating procedures. Once being digested and absorbed into the circulation, two separate pathways can be involved in the deleterious effects of dAGEs: an AGE receptor‐dependent way to stimulate cell signals, and an AGE receptor‐independent way to dysregulate proteins via forming complexes. Inhibition of AGEs formation during food processing and reduction in the diet are two potent approaches to restrict health‐hazardous dAGEs. To elucidate the biological role of dAGEs toward human health, the following significant perspectives are raised: molecular size and complexity of dAGEs; interactions between unabsorbed dAGEs and gut microbiota; and roles played by concomitant compounds in the heat‐processed foods.

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Section: Health Implications Of Dages: Perspectives To Fill the Gap Bmentioning

confidence: 99%

Dietary advanced glycation end‐products: Perspectives linking food processing with health implications

Zhang

2020

Comp Rev Food Sci Food Safe

144

116

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“…The underlying mechanism behind those effects was found to be increased number of islet cells and basal insulin (Liao and Lin, 2013a). Oligomeric procyanidins from N. nucifera seedpod have been reported to inhibit AGE formation through activation of RAGE-MAPK and NF-κB signaling in high-fat-diet rats (Wu et al, 2015b). Tsuruta et al reported that N. nucifera root powder suppresses the progression of non-alcoholic…”

Section: Phytochemical Profiling Of Lotusmentioning

confidence: 99%

A Comprehensive Review on Chemical Profiling of Nelumbo Nucifera: Potential for Drug Development

Sharma

Gautam

Adhikari³

et al. 2016

Phytotherapy Research

143

107

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Nelumbo nucifera, also known as sacred lotus, has primarily been used as food throughout the Asian continent, and its medicinal values have been described in Ayurvedic and Traditional Chinese Medicine. The purpose of this study is to systematically characterize the chemical profiling and pharmacological activities of N. nucifera. Herein, we critically reviewed and analysed the phytochemical and pharmacological reports of N. nucifera. Our search for the keyword 'Nelumbo nucifera pharmacology' in all databases reported in Web of Science yielded 373 results excluding reviews and abstracts in document types. Two hundred and forty-three spectrum natural compounds from different parts of N. nucifera belonging to diverse chemical groups, including alkaloids, flavonoids, glycosides, terpenoids, steroids, fatty acids, proteins, minerals, and vitamins have been reported. In addition, distinct pharmacological activities, mainly against cancer, microbial infection, diabetes, inflammation, atherosclerosis, and obesity, have been associated with crude extracts, fractions, and isolated compounds. This review highlights potential use of neferine, liensinine, isoliensinine, and nuciferine in clinical trials. In depth, mechanism of the potential chemical entities from N. nucifera via structure activity relationship needs to be explored to guarantee the stability and safety for the clinical use. Copyright © 2016 John Wiley & Sons, Ltd.

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“…Besides, HFD is reported to upregulate kidney TLR4/ NF-kB signaling pathway and inflammation-related chemokines. 40,41 In this regard, Emr-1, MCP-1, MIP-1α, Cxcr4, and TLR4/NF-kB signaling-related indicators were tested. As shown in Figure 4A-D, significant increases in mRNA of inflammation-related factors, including Emr-1, MCP-1, MIP-1α, and Cxcr4, were observed in the HFD group, suggesting that fat-rich diet activates the inflammatory responses and cellular infiltration.…”

mentioning

confidence: 99%

Gold-quercetin nanoparticles prevent metabolic endotoxemia-induced kidney injury by regulating TLR4/NF-kB signaling and Nrf2 pathway in high fat diet fed mice

Xu¹,

Wang²,

Yang³

2017

IJN

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Inhibition of Advanced Glycation Endproduct Formation by Lotus Seedpod Oligomeric Procyanidins through RAGE–MAPK Signaling and NF-κB Activation in High-Fat-Diet Rats

Cited by 46 publications

References 45 publications

Dietary advanced glycation end‐products: Perspectives linking food processing with health implications

Dietary advanced glycation end‐products: Perspectives linking food processing with health implications

A Comprehensive Review on Chemical Profiling of Nelumbo Nucifera: Potential for Drug Development

Gold-quercetin nanoparticles prevent metabolic endotoxemia-induced kidney injury by regulating TLR4/NF-kB signaling and Nrf2 pathway in high fat diet fed mice

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