Inhibition of airway inflammation, hyperresponsiveness and remodeling by soy isoflavone in a murine model of allergic asthma

Bao, Zhao-Seng; Li, Hong; Guan, Yan; Dong, Xiaopeng; Zheng, Hua-Sheng; Tan, Gong-Li; Xie, Qiang-min

doi:10.1016/j.intimp.2011.02.001

Cited by 47 publications

(27 citation statements)

References 30 publications

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“…Our results confirmed significantly higher serum IL-4 levels in atopic asthmatic children as compared to controls. Supporting our findings, Bao et al [20], Shi et al [21], Wu et al, [22] and Nesi et al [23] revealed a significant increase in IL-4 in ovalbumininduced asthmatic mice compared to the control. Our finding may also be reinforced in the light of observations of Antczak et al [5] who found higher mRNA level of IL-4 and IL-13 genes in asthmatic patients when compared to controls.…”

Section: Discussionsupporting

confidence: 90%

Association of STAT6 rs324011 Gene Polymorphism with Susceptibility of Atopic Bronchial Asthma in Egyptian Children

El-Gohary¹,

Wagih²,

Hamouda³

et al. 2018

Biochem Mol biol J

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Background: Bronchial asthma is a common disease with multiple determinants that include genetic variation. Signal transducer and activator of transcription 6 (STAT6) is a central molecule in the signal transduction pathway used by interleukin-4 (IL-4) in immunoglobulin E (IgE) isotype switching. Study Objective was to investigate whether single nucleotide polymorphism (SNP) in STAT6 is associated with atopic asthma susceptibility in Egyptian children and to correlate the effect of STAT6 gene polymorphism on IL-4 and total IgE levels.

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Section: Discussionsupporting

confidence: 90%

Association of STAT6 rs324011 Gene Polymorphism with Susceptibility of Atopic Bronchial Asthma in Egyptian Children

El-Gohary¹,

Wagih²,

Hamouda³

et al. 2018

Biochem Mol biol J

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“…Airway inflammation and remodeling are the two characterized pathological [15,16] . Among the inflammatory cells participated in occurrence and development of asthma, eosinophils play a featured role [17,18] .…”

Section: Discussionmentioning

confidence: 99%

The PPARγ agonist, rosiglitazone, attenuates airway inflammation and remodeling via heme oxygenase-1 in murine model of asthma

Zhu

Wang

et al. 2015

Acta Pharmacol Sin

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Aim: Rosiglitazone is one of the specific PPARγ agonists showing potential therapeutic effects in asthma. Though PPARγ activation was considered protective in inhibiting airway inflammation and remodeling in asthma, the specific mechanisms are still unclear. This study was aimed to investigate whether heme oxygenase-1 (HO-1) related pathways were involved in rosiglitazone-activated PPARγ signaling in asthma treatment. Methods: Asthma was induced in mice by multiple exposures to ovalbumin (OVA) in 8 weeks. Prior to every OVA challenge, the mice received rosiglitazone (5 mg/kg, po). After the mice were sacrificed, the bronchoalveolar lavage fluid (BALF), blood samples and lungs were collected for analyses. The activities of HO-1, MMP-2 and MMP-9 in airway tissue were assessed, and the expression of PPARγ, HO-1 and p21 proteins was also examined. Results: Rosiglitazone administration significantly attenuated airway inflammation and remodeling in mice with OVA-induced asthma, which were evidenced by decreased counts of total cells, eosinophils and neutrophils, and decreased levels of IL-5 and IL-13 in BALF, and by decreased airway smooth muscle layer thickness and reduced airway collagen deposition. Furthermore, rosiglitazone administration significantly increased PPARγ, HO-1 and p21 expression and HO-1 activity, decreased MMP-2 and MMP-9 activities in airway tissue. All the therapeutic effects of rosiglitazone were significantly impaired by co-administration of the HO-1 inhibitor ZnPP. Conclusion: Rosiglitazone effectively attenuates airway inflammation and remodeling in OVA-induced asthma of mice by activating PPARγ/HO-1 signaling pathway.

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“…Daily administration also markedly suppressed, in a dose dependent manner, the eotaxin, IL-5, IL-4 and matrix metalloproteinase-9 (MMP-9) mRNAs, augment the expression of interferon (IFN-γ) mRNA and the expression of tissue inhibitor of metalloproteinase-1 (TIMP-1). Moreover, these compounds also inhibit airway mucus production and extracellular matrix remodeling in lung tissues which can be observed through histological studies [123].…”

Section: Asthmamentioning

confidence: 99%

Structure-Activity Association of Flavonoids in Lung Diseases

et al. 2014

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Flavonoids are polyphenolic compounds classified into flavonols, flavones, flavanones, isoflavones, catechins, anthocyanidins, and chalcones according to their chemical structures. They are abundantly found in Nature and over 8,000 flavonoids have from different sources, mainly plant materials, have been described. Recently reports have shown the valuable effects of flavonoids as antiviral, anti-allergic, antiplatelet, antitumor, antioxidant, and anti-inflammatory agents and interest in these compounds has been increasing since they can be helpful to human health. Several mechanisms of action are involved in the biological properties of flavonoids such as free radical scavenging, transition metal ion chelation, activation of survival genes and signaling pathways, regulation of mitochondrial function and modulation of inflammatory responses. The anti-inflammatory effects of flavonoids have been described in a number of studies in the literature, but not frequently associated to respiratory disease. Thus, this review aims to discuss the effects of different flavonoids in the control of lung inflammation in some disorders such as asthma, lung emphysema and acute respiratory distress syndrome and the possible mechanisms of action, as well as establish some structure-activity relationships between this biological potential and chemical profile of these compounds.

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Inhibition of airway inflammation, hyperresponsiveness and remodeling by soy isoflavone in a murine model of allergic asthma

Cited by 47 publications

References 30 publications

Association of STAT6 rs324011 Gene Polymorphism with Susceptibility of Atopic Bronchial Asthma in Egyptian Children

Association of STAT6 rs324011 Gene Polymorphism with Susceptibility of Atopic Bronchial Asthma in Egyptian Children

The PPARγ agonist, rosiglitazone, attenuates airway inflammation and remodeling via heme oxygenase-1 in murine model of asthma

Structure-Activity Association of Flavonoids in Lung Diseases

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