Inhibition of Allergen-Induced Airway Inflammation by Low-Dose Oral Immunotherapy with Transgenic Rice Seeds Independently of Immunoglobulin E Synthesis

Saeki, Mayumi; Nishimura, Tomoe; Kaminuma, Osamu; Suzuki, Kazuya; Takai, Toshiro; Mori, Akio; Takada, Kazuko; Takaiwa, Fumio; Hiroi, Takachika

doi:10.1159/000337771

Cited by 5 publications

(3 citation statements)

References 34 publications

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“…Genetically modified food was first used a few years ago for AI [61] [62] and this method requires further thorough and specific studies.…”

Section: Discussionmentioning

confidence: 99%

Pathophysiological Justification for Allergen Immunotherapy in Food Allergy

Chełmińska¹,

Puźniakowska²

2016

FNS

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Apart from avoiding exposure, allergen immunotherapy (AI) is the only causal method of treating allergic diseases. The results of numerous studies have been published concerning the safety and effectiveness of the AI in treating allergic rhinitis, asthma or allergy to the venom of Hymenoptera insects. It has also been proven that administration of increasing preparation doses of allergen extractions alleviates the symptoms in patients after the exposure to some sensitizing allergens. The effect of the AI remains visible many years after completion of the therapy. Studies have been done in an attempt to employ specific immunotherapy in patients with food allergy symptoms. They have been mostly concerned with populations of patients suffering from allergy to the protein found in cow's milk and hen eggs. It appears that a need arises to create a new therapeutic method for successful treatment of food allergies and specific allergen immunotherapy seems to be a promising step. Although still in its experimental phase, in many well documented cases the method allows for building patient's tolerance towards small doses of sensitizing allergen and seems conducive to protecting the patient from anaphylactic reactions after incidental allergen consumption.

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“…Genetically modified food was first used a few years ago for AI [61] [62] and this method requires further thorough and specific studies.…”

Section: Discussionmentioning

confidence: 99%

Pathophysiological Justification for Allergen Immunotherapy in Food Allergy

Chełmińska¹,

Puźniakowska²

2016

FNS

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“…Another area of related research is that on allergens. For example, GM rice seeds have been used for the production of a recombinant hypoallergenic birch pollen allergen Bet v 1 (Wang et al, 2013d), and a hypoallergenic Der f 2 (Yang et al, 2012a) and Der p 1 (Saeki et al, 2012(Saeki et al, , 2013 pteronyssinus. These products may be useful in allergen-specific immunotherapy.…”

Section: Enzymes Diagnostics and Vaccinesmentioning

confidence: 99%

Transgenic cereals: Current status and future prospects

Dunwell

2014

Journal of Cereal Science

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This review summarises the history of transgenic (GM) cereals, principally maize, and then focuses on the scientific literature published in the last two years. It describes the production of GM cereals with modified traits, divided into input traits and output traits. The first category includes herbicide tolerance and insect resistance, and resistance to abiotic and biotic stresses; the second includes altered grains for starch, protein or nutrient quality, the use of cereals for the production of high value medical or other products, and the generation of plants with improved efficiency of biofuel production. Using data from field trial and patent databases the review considers the diversity of GM lines being tested for possible future development. It also summarises the dichotomy of response to GM products in various countries, describes the basis for the varied public acceptability of such products, and assesses the development of novel breeding techniques in the light of current GM regulatory procedures.

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“…5 g/kg/day) of Der p 1 Tg rice, compared with the dose employed in the above experiment (approx. 50 g/kg/day), also suppressed allergen-induced infiltration of inflammatory cells into the lungs, whereas allergen-specific IgE production was not affected [37]. Even though the reason for the difference in the effect on IgE production between high-dose and low-dose Der p 1 Tg rice is unclear, the effectiveness of oral IT with Tg rice in allergic diseases may be caused, at least in part, by mechanisms other than the downregulation of IgE synthesis.…”

Section: Effect Of Tg Rice In a Murine Model Of Bronchial Asthmamentioning

confidence: 99%

Oral Immunotherapy for Allergic Diseases Using Transgenic Rice Seeds: Current State and Future Prospects

Saeki

Nishimura²,

Kaminuma³

et al. 2013

Int Arch Allergy Immunol

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Allergen-specific immunotherapy (IT) has been shown to provide clinical benefit for patients with allergic diseases. At present, subcutaneous and sublingual ITs are mainly authorized for clinical treatment. Oral administration of allergens seems to be the easiest way to achieve IT, though it has yet to be translated to the clinical setting, mainly due to the requirement of a large amount of allergens. Plants, especially rice seeds, have recently been recognized as superior allergen carriers for oral administration, because of their high productivity, stability and safety. Therefore, in order to establish clinically applicable oral IT, we have been developing transgenic rice seeds (Tg rice), in which major epitopes of cedar pollen allergens or house-dust mites (HDM) are expressed. The efficacy of this orally administered Tg rice was confirmed in murine models of allergic rhinitis and bronchial asthma. In the safety study of the Tg rice, no adverse effects on cynomolgus macaques were observed. In this review, we summarized the current state and future prospects of allergen-specific IT, focusing particularly on oral IT with allergen-expressing Tg rice.

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Inhibition of Allergen-Induced Airway Inflammation by Low-Dose Oral Immunotherapy with Transgenic Rice Seeds Independently of Immunoglobulin E Synthesis

Cited by 5 publications

References 34 publications

Pathophysiological Justification for Allergen Immunotherapy in Food Allergy

Pathophysiological Justification for Allergen Immunotherapy in Food Allergy

Transgenic cereals: Current status and future prospects

Oral Immunotherapy for Allergic Diseases Using Transgenic Rice Seeds: Current State and Future Prospects

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