Inhibition of AMP-activated protein kinase in respiratory syncytial virus infection activates lipid metabolism

González-García, Luis Didier; Martínez-Castillo, Macario; Vargas-Pavía, Tania Allin; Ulloa-Aguilar, José Manuel; Romero, Hugo; León-Reyes, Guadalupe; Helguera-Repetto, Addy Cecilia; García‐Cordero, Julio; León-Juárez, Moisés

doi:10.1007/s00705-021-04974-7

Cited by 2 publications

(1 citation statement)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Activation of AMPK restricts Coxsackie virus B3 (CVB3) replication by inhibiting lipid accumulation [ 129 ]. A recent publication by González-García et al, reported that respiratory syncytial virus (RSV) infection activates AKT-dependent inhibition of AMPK, and induces the activation of downstream lipogenic effectors and cellular lipid anabolism [ 130 ]. DENV upregulates the HMG-CoA reductase activity through the impairment of AMPK phosphorylation, and a reduction of AMPK phosphorylation activity was observed in DENV-infected cells at 12 and 24 hpi.…”

Section: Interaction Between Viruses and Ampk Pathwaysmentioning

confidence: 99%

Multifaceted Role of AMPK in Viral Infections

Bhutta

Gallo²,

Borenstein

2021

Cells

View full text Add to dashboard Cite

Viral pathogens often exploit host cell regulatory and signaling pathways to ensure an optimal environment for growth and survival. Several studies have suggested that 5′-adenosine monophosphate-activated protein kinase (AMPK), an intracellular serine/threonine kinase, plays a significant role in the modulation of infection. Traditionally, AMPK is a key energy regulator of cell growth and proliferation, host autophagy, stress responses, metabolic reprogramming, mitochondrial homeostasis, fatty acid β-oxidation and host immune function. In this review, we highlight the modulation of host AMPK by various viruses under physiological conditions. These intracellular pathogens trigger metabolic changes altering AMPK signaling activity that then facilitates or inhibits viral replication. Considering the COVID-19 pandemic, understanding the regulation of AMPK signaling following infection can shed light on the development of more effective therapeutic strategies against viral infectious diseases.

show abstract

Section: Interaction Between Viruses and Ampk Pathwaysmentioning

confidence: 99%