Inhibition of angiotensin-converting enzyme by aqueous extract of tomato

Biswas, Dipankar; Uddin, Md. Main; Dizdarevic, Lili L; Jørgensen, Aud; Duttaroy, Asim K.

doi:10.1007/s00394-014-0676-1

Cited by 31 publications

(24 citation statements)

References 35 publications

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“…The mechanism of hypotensive effect of the extract is not fully explained. It is assumed, however, that it can reduce expression of renin and angiotensin-converting enzyme (ACE) [10]. Another mechanism through which STE can potentially lower BP is via an increase of the nitric oxide production, which subsequently leads to vasodilation [11].…”

Section: Introductionmentioning

confidence: 99%

Favourable hypotensive effect after standardised tomato extract treatment in hypertensive subjects at high cardiovascular risk: a randomised controlled trial

Krasińska¹,

Osińska

Krasińska

et al. 2018

Kardiol Pol

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The results of this study show that the addition of STE to standard antihypertensive therapy improves BP control in hypertensive patients with high CV risk. This effect, together with the anti-aggregatory effect, may indicate the pleiotropic effect of tomato extract. This fact justifies further research into functional foods and gives new insights into STE as a food supplement that could have new therapeutic and prophylactic uses for the treatment of hypertensive patients with high CV risk and especially with obesity.

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Section: Introductionmentioning

confidence: 99%

Favourable hypotensive effect after standardised tomato extract treatment in hypertensive subjects at high cardiovascular risk: a randomised controlled trial

Krasińska¹,

Osińska

Krasińska

et al. 2018

Kardiol Pol

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“…Tomato juice was earlier shown to lower blood pressure in human volunteers, and this effect was thought to be associated with its high antioxidant content [99, 100]. We therefore tested whether Fruitflow ® inhibited human serum ACE activity and rabbit lung ACE activity [17]. The IC 50 value of Fruitflow ® for ACE inhibition in serum was 1.91 ± 0.24 mg/ml (0.038 μg catechin equivalent(CE)/ml), whereas for captopril, the value was 0.56 ± 0.08 μg/ml.…”

Section: New Functionalities Of Fruitflow®: Anti-inflammatory and Blomentioning

confidence: 99%

“…In a variety of studies, it was demonstrated that water-soluble components of tomatoes are capable of inhibiting platelet aggregation both in vitro and in vivo [13–16]. These water-soluble tomato components were also found to inhibit angiotensin-converting enzyme (ACE) and to relax the vascular endothelium, the other important limbs of the cardiovascular system [17, 18]. A water-soluble tomato extract containing all the bioactive components was developed and later given the trade name Fruitflow ® .…”

Section: Introductionmentioning

confidence: 99%

Fruitflow®: the first European Food Safety Authority-approved natural cardio-protective functional ingredient

O’Kennedy

Raederstorff²,

Duttaroy

2016

Eur J Nutr

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Hyperactive platelets, in addition to their roles in thrombosis, are also important mediators of atherogenesis. Antiplatelet drugs are not suitable for use where risk of a cardiovascular event is relatively low. It is therefore important to find alternative safe antiplatelet inhibitors for the vulnerable population who has hyperactive platelets in order to reduce the risk of cardiovascular disease. Potent antiplatelet factors were identified in water-soluble tomato extract (Fruitflow®), which significantly inhibited platelet aggregation. Human volunteer studies demonstrated the potency and bioavailability of active compounds in Fruitflow®. Fruitflow® became the first product in Europe to obtain an approved, proprietary health claim under Article 13(5) of the European Health Claims Regulation 1924/2006 on nutrition and health claims made on foods. Fruitflow® is now commercially available in different countries worldwide. In addition to its reduction in platelet reactivity, Fruitflow® contains anti-angiotensin-converting enzyme and anti-inflammatory factors, making it an effective and natural cardio-protective functional food.

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“…It has also been demonstrated that STE reduces the expression of cell adhesion molecules (ICAM-1, VCAM-1) in endothelial cells, which play an important role in the formation of atherosclerotic plaque [27]. Furthermore, there are reports describing the role of hypotensive properties of STE polyphenols in the mechanism of angiotensin-converting enzyme (ACE) inhibition [29]. In 2015, the guidelines of the Polish Society of Hypertension for the first time allowed the use of other substances (including STE) as alternatives to ASA.…”

Section: Standardized Tomato Extract In the Primary Prophylaxis Of Ismentioning

confidence: 99%

Antiplatelet treatment in the primary prophylaxis of cardiovascular disease in patients with arterial hypertension

Osińska

Osiński

Krasińska

et al. 2017

kitp

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The benefits of using acetylsalicylic acid (ASA) in the primary prophylaxis of cardiovascular diseases may only slightly exceed the risk of serious bleeding. This warrants the search for alternative, safer preparations with antiaggregatory properties, which could be used in patients burdened with cardiovascular risk factors. Antiaggregatory compounds identified in water-soluble tomato extract include nucleosides, flavonoids, and phenolic acids. The action of standardized tomato extract is multidirectional, reversible, and weaker in comparison to ASA. The European Food Safety Authority (EFSA) has approved this preparation as a dietary agent with antiaggregatory properties. The use of standardized tomato extract appears beneficial in arterial hypertension patients with low or moderate cardiovascular risk and in patients in whom good pressure control cannot be achieved.

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Inhibition of angiotensin-converting enzyme by aqueous extract of tomato

Abstract: Together these data indicate that aqueous extract of tomatoes contain anti-ACE factors in addition to previously described anti-platelet factors.

Cited by 31 publications

References 35 publications

Favourable hypotensive effect after standardised tomato extract treatment in hypertensive subjects at high cardiovascular risk: a randomised controlled trial

Favourable hypotensive effect after standardised tomato extract treatment in hypertensive subjects at high cardiovascular risk: a randomised controlled trial

Fruitflow®: the first European Food Safety Authority-approved natural cardio-protective functional ingredient

Antiplatelet treatment in the primary prophylaxis of cardiovascular disease in patients with arterial hypertension

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