Inhibition of angiotensin II action protects rat steatotic livers against ischemia-reperfusion injury

Angiotensin-(1–7) reduces the perfusion pressure response to angiotensin II and methoxamine via an endothelial nitric oxide-mediated pathway in cirrhotic rat liver

“…The vasodilatory effects of Ang- (1)(2)(3)(4)(5)(6)(7) are NOS and guanylate cyclase dependent. We then investigated the intracellular mechanisms that might be responsible for the effects of Ang-(1-7).…”

“…There was one additional group in which both AT1R and Mas receptor were blocked. The doses of lisinopril, candesartan, PD123319, JE049, A779, AVE0991, D-Pro 7 -Ang-(1-7), L-NAME, and ODQ were based on our laboratory's preliminary investigations and published studies (1,7,8,15,26,39,45,46). To determine whether Ang-(1-7) affected the response to another major mediator of hepatic vascular tone and to dissect out the involvement of AT1R in the Ang-(1-7) signaling pathway, we administered the ␣-adrenergic agonist MTX in two groups using the same design as for Ang II; one group of livers was perfused in the presence of the AT1R blocker candesartan and the other with candesartan plus the Mas receptor blocker A779.…”

“…It is now known that there is an alternate arm of the RAS in which ACE2, a homolog of ACE, degrades Ang II and generates angiotensin-(1-7) [Ang- (1)(2)(3)(4)(5)(6)(7)], which has a number of effects that appear to oppose those of Ang II. These effects are mediated in part by the Mas receptor, a novel endogenous G-protein-coupled receptor (GPCR) (14,22,24,34,40,47).…”

Are Angiotensin II Receptor Antagonists Useful Strategies in Steatotic and Nonsteatotic Livers in Conditions of Partial Hepatectomy under Ischemia-Reperfusion?

“…Two studies on partial hepatectomy without I/R gave opposite results on the effect of angiotensin (Ang) II receptor antagonists on liver regeneration (Ramalho et al, 2002;Yayama et al, 2007). Other studies on I/R without partial hepatectomy reported beneficial effects of Ang II receptor antagonists on hepatic damage (Guo et al, 2004;Casillas-Ramirez et al, 2008). The effect of Ang II receptor antagonists on liver regeneration and damage in conditions of partial hepatectomy under I/R has not been examined.…”

“…A number of studies suggest that a local renin-angiotensin system is present in the liver that exerts blood pressureindependent actions, including effects on hepatocellular proliferation and damage (Ramalho et al, 2002;Guo et al, 2004;Yayama et al, 2007;Casillas-Ramirez et al, 2008). Two studies on partial hepatectomy without I/R gave opposite results on the effect of angiotensin (Ang) II receptor antagonists on liver regeneration (Ramalho et al, 2002;Yayama et al, 2007).…”