“…For example, in cancer, autophagy can act as a tumor suppressor during the initial stages of tumor progression, but may promote tumor cell survival in later stages (Tu et al, 2011; Mah & Ryan, 2012; Kaminskyy et al, 2012; Huang et al, 2014; Morgan et al, 2014; Galluzzi et al, 2015). Lefort et al (2014) have shown that autophagy-linked genes are upregulated in TNBC cell lines, including the HCC70 cell line that was used in the current study, cultured in a laminin-rich extracellular matrix (Lefort et al, 2014). Moreover, TNBC cell lines, including HCC70, appear to respond to the suppression of the NEET family proteins, mitoNEET (mNT) and Nutrient-deprivation autophagy factor-1 (NAF-1), with impaired ultrastructural mitochondrial morphology and autophagosome accumulation (Sohn et al, 2013).…”