Inhibition of autophagy augments 5-fluorouracil chemotherapy in human colon cancer in vitro and in vivo model

Li, Jie; Hou, Ni; Faried, Ahmad; Tsutsumi, Soichi; Kuwano, Hiroyuki

doi:10.1016/j.ejca.2010.02.021

Cited by 280 publications

(198 citation statements)

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“…Inhibition of autophagy by use of chloroquine or Atg5 knockdown has been shown to enhance tumor death induced by p53 or alkylating drugs [184]. In addition, use of 3-MA or Atg7 knockdown in 5-fluorouraciltreated cancer cells enhances apoptosis induction [185]. These data demonstrate a potential role for autophagy inhibitors in combination with conventional therapies in sensitizing apoptosis induction in human cancers.…”

Section: Autophagy In Tumorigenesis and Cancer Treatmentmentioning

confidence: 67%

Autophagy: for better or for worse

et al. 2011

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Autophagy is a lysosomal degradation pathway that degrades damaged or superfluous cell components into basic biomolecules, which are then recycled back into the cytosol. In this respect, autophagy drives a flow of biomolecules in a continuous degradation-regeneration cycle. Autophagy is generally considered a pro-survival mechanism protecting cells under stress or poor nutrient conditions. Current research clearly shows that autophagy fulfills numerous functions in vital biological processes. It is implicated in development, differentiation, innate and adaptive immunity, ageing and cell death. In addition, accumulating evidence demonstrates interesting links between autophagy and several human diseases and tumor development. Therefore, autophagy seems to be an important player in the life and death of cells and organisms. Despite the mounting knowledge about autophagy, the mechanisms through which the autophagic machinery regulates these diverse processes are not entirely understood. In this review, we give a comprehensive overview of the autophagic signaling pathway, its role in general cellular processes and its connection to cell death. In addition, we present a brief overview of the possible contribution of defective autophagic signaling to disease.

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Section: Autophagy In Tumorigenesis and Cancer Treatmentmentioning

confidence: 67%

Autophagy: for better or for worse

et al. 2011

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“…17,18 A series of studies reported that chemotherapy induced-autophagy promotes the survival of some kinds of cancer cell lines. [19][20][21][22][23] These results suggest that autophagy might be involved in the development of chemotherapy resistance. But few studies on the relationship between autophagy and chemotherapy were reported, especially studies utilizing resistant cancer cells.…”

Section: ©2 0 1 1 L a N D E S B I O S C I E N C E D O N O T D I S Tmentioning

confidence: 85%

Autophagy protects breast cancer cells from epirubicin-induced apoptosis and facilitates epirubicin-resistance development

Sun¹,

Chen²,

Wang³

et al. 2011

Autophagy

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“…According these results, the autophagy induced by anti-cancer agents was mainly divided into two types: one is the protective antophagy that serve as a protective mechanism against apoptosis; the other is called autophagic cell death that can result in cell death. There is emerging evidence that protective autophagy plays an important role in cellular resistance to chemotherapy (Herman-Antosiewicz et al, 2006;Li et al, 2010). In our study, we investigated the contributions of autophagy to the survival of GBM cells during GA-induced apoptotic cell death.…”

Section: Discussionmentioning

confidence: 99%