Inhibition of B‐cell death does not restore T‐cell‐dependent immune responses in CD40‐deficient mice

Abstract

SUMMARYSignalling through CD40 is essential for the development of immunoglobulin G (IgG) antibody responses, germinal centres and B-cell memory against T-dependent antigens. In addition, engagement of CD40 in B cells promotes cell survival by inducing the expression of anti-apoptotic members of the bcl-2 family of cell-death regulators. In the present study we analysed whether Tdependent immune responses can be developed in mice de®cient in CD40 if the anti-apoptotic activity mediated by the engagement of CD40 in B cells is compensated by the constitutive overexpression of anti-apoptotic genes of the bcl-2 family. We showed that the over-expression of either hbcl-2 or hbcl-x L transgenes in B cells is not suf®cient to restore IgG antibody responses and germinal centre formation in CD40-de®cient mice. These results indicate that CD40 functions, other than those mediated through survival, are required for the establishment of T-dependent B-cell responses.

Actividad física y bienestar social para gestantes del centro de salud Montecristi

“…La actividad física es todo movimiento corpóreo leve, moderado e intenso que implica gasto energético, por esto se dice que su ejecución es de gran beneficio para el individuo. Merino-Merino et al (2006)…”