Inhibition of Bacterial Adhesion by Sub-Inhibitory Concentrations: Brodimoprim vs Trimethoprim

Braga, Pier Carlo; Piatti, G.; Limoli, A; Santoro, Maurício; Gazzola, T.

doi:10.1080/1120009x.1993.11741094

Cited by 5 publications

(3 citation statements)

References 8 publications

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“…However, comparisons of the pharmacokinetic curves and MICs or MBCs have shown that the latter exceed inhibitory concentrations for only limited periods of time, after which they become less than the MIC in the time interval between doses and are called subinhibitory concentrations (sub-MICs). This is clearly visible in the peripheral compartments, in which antibiotic concentrations are frequently lower than those in blood 29 .…”

Section: Discussionmentioning

confidence: 92%

“…Antibiotics are used to counteract this situation when the natural clearance mechanisms and/or cellular defenses are overwhelmed. Their action is described in terms of their ability to kill or inhibit the growth of the pathogens, which is why much attention has been paid to inhibitory concentrations (MIC, MBC) and exceeding the MIC or MBC at the site of infection 29 . However, comparisons of the pharmacokinetic curves and MICs or MBCs have shown that the latter exceed inhibitory concentrations for only limited periods of time, after which they become less than the MIC in the time interval between doses and are called subinhibitory concentrations (sub-MICs).…”

Section: Discussionmentioning

confidence: 99%

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Morphostructural Damage and the Inhibition of Bacterial Adhesiveness ofStaphylococcus aureusandMoraxella catarrhalisInduced by Moxifloxacin

Braga

Culici²,

Ricci³

et al. 2003

Journal of Chemotherapy

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The aim of this study was to investigate the ability of moxifloxacin to interfere with the mechanism of bacterial adhesion and disrupt the morphological and structural integrity of bacteria. Three Staphylococcus aureus and three Moraxella catarrhalis strains were grown in the presence of 1/2-1/128 minimum inhibitory concentration (MIC) serial dilutions and incubated with human epithelial cells. A significant decrease in adhesion was observed from 1/2 MIC to 1/64 MIC for S. aureus, and from 1/2 MIC to 1/16 MIC for M. catarrhalis. The use of atomic force microscopy, a new technique capable of revealing surface structures in three-dimensional detail and at very high resolution, showed the rapid onset and time course of the sequence of disruptive morphostructural events following the incubation of both S. aureus and M. catarrhalis with sub-MICs of moxifloxacin. Our findings suggest that less than conventional MIC moxifloxacin concentrations may be effective in reducing bacterial adhesiveness and structural integrity on which the maintenance of bacterial activity depends.

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Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Morphostructural Damage and the Inhibition of Bacterial Adhesiveness ofStaphylococcus aureusandMoraxella catarrhalisInduced by Moxifloxacin

Braga

Culici²,

Ricci³

et al. 2003

Journal of Chemotherapy

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“…References for further reading [15,19]. The values above are expressed as ratio to the control (without antibiotic) which is fixed arbitrarily at 1.0.…”

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confidence: 99%

Intermedilysin release byStreptococcus intermedius: effects of various antibacterial drugs at sub-MIC levels

Taylor¹,

Kang

et al. 2005

FEMS Microbiology Letters

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Intermedilysin is a cytolytic toxin produced by Streptococcus intermedius, a pathogen of humans. In vitro studies showed that exposure of S. intermedius to sub-minimum inhibitory concentration (MIC) levels (1/2 MIC) of protein-inhibiting antibiotics and nucleic acid-inhibiting antibiotics decreased intermedilysin release by S. intermedius. The most potent antibiotic was clindamycin. On the other hand, exposure to cell wall-inhibiting antibiotics generally showed insignificant changes in intermedilysin release at sub-MIC concentrations. Investigations into possible mechanisms underlying this sub-MIC effect with clindamycin showed that there was selective decrease in biosynthesis and release of toxin after exposure to 1/2 MIC condition. However, no significant differences in the mRNA levels of the intermedilysin gene were observed.

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Folate inhibitors

Hills¹,

Weston²,

Norrby³

2010

Infectious Diseases

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Inhibition of Bacterial Adhesion by Sub-Inhibitory Concentrations: Brodimoprim vs Trimethoprim

Cited by 5 publications

References 8 publications

Morphostructural Damage and the Inhibition of Bacterial Adhesiveness ofStaphylococcus aureusandMoraxella catarrhalisInduced by Moxifloxacin

Morphostructural Damage and the Inhibition of Bacterial Adhesiveness ofStaphylococcus aureusandMoraxella catarrhalisInduced by Moxifloxacin

Intermedilysin release byStreptococcus intermedius: effects of various antibacterial drugs at sub-MIC levels

Folate inhibitors

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