Inhibition of bacterial colonization by antimicrobial agents incorporated into dental resins

Abstract

The antimicrobial activity of several chemical agents was determined by incorporating these agents into dentine adhesive resin and following the colonization of Streptococcus mutans on the surfaces of the resin and culture vessel, as well as in the surrounding medium, by optical density measurements. It was found that sodium fluoride and dodecylamine, an organic amine, exhibited excellent antimicrobial properties. These chemicals not only inhibited bacterial growth completely but also seemed to reduce the adhesion of the bacteria to the resin surface. A silver compound, protargin, was mildly effective in inhibiting growth of S. mutans. Copper oxide and chelating acids such as vanillic acid, syringic acid, and ethylenediamine-n, n' diacetic acid (EDDA) were not effective as antimicrobial agents against S. mutans.

Antimicrobial properties of conventional restorative filling materials and advances in antimicrobial properties of composite resins and glass ionomer cements—A literature review

“…Silver compounds have been known to possess anticariogenic properties for more than a century [126], so it comes to as no surprise that resins leaching silver in situ or containing silver compounds have been introduced to dental material [2,15,19,20,127,128]. Silver ions have been shown to inactivate enzymes and hinder DNA replication in bacteria, especially when in the nano-particulate form, due to the high surface-area-to-volume ratio.…”

Effects of a dental adhesive incorporating antibacterial monomer on the growth, adherence and membrane integrity of Streptococcus mutans

“…2,3 Therefore, attempts of functionalizing adhesive system with antibacterial activity have been made to ensure the biological sealing of the restoration even when microleakage occurs. [4][5][6][7][8][9] A number of reports have described the addition of antibacterial components, such as antibiotics, inorganic agents and fluorides, in the constituents of dental adhesive system. 4,[8][9][10][11] However, since antibacterial agents are only simply dispersed in matrix phase, it is impossible to get a strict control of the release kinetics.…”

Effect of a Novel Quaternary Ammonium Methacrylate Polymer (QAMP) on Adhesion and Antibacterial Properties of Dental Adhesives

“…In order to avoid this adverse condition, adhesive systems should present a long-lasting antibacterial activity for bacteria that enter this interface, leading to microleakage [1–3]. Accordingly, some antimicrobials freely dispersed into adhesive systems such as antibiotics, quaternary ammonium compounds glutaraldehyde, and fluorides have been extensively evaluated [4–11]. However these freely dispersed agents are inappropriately released from restorative material and result in decreased bond strength for restoration [11,12].…”