2023
DOI: 10.21203/rs.3.rs-2609743/v1
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Inhibition of beta oscillations by delayed feedback in a cortex-basal ganglia-thalamus-pedunculopontine nucleus neural loop model

Abstract: Excessive neural synchronization of neural populations in the beta (β) frequency range (12-35Hz) is intimately related to the symptoms of hypokinesia in Parkinson's disease (PD). Studies have shown that delayed feedback strategies can interrupt excessive neural synchronization and thus effectively alleviate symptoms associated with PD dyskinesia. Work on optimizing delayed feedback algorithms continues to progress, yet it remains challenging to further improve the inhibitory effect with reduced energy expendit… Show more

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