Inhibition of Bone Metastasis from Breast Carcinoma by Rosmarinic Acid

Jiang, Zhiyong; Ji, Guang; Liu, Jianwen

doi:10.1055/s-0029-1240893

Cited by 64 publications

(46 citation statements)

References 29 publications

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“…Study in Ls174-T human colon carcinoma cells found that rosmarinic acid inhibits migration, adhesion, and invasion dose-dependently [176]. In another study, rosmarinic acid may inhibit bone metastasis from breast carcinoma mainly via the pathway of the NF-κB and by simultaneous suppression of interleukin-8 (IL-8) [177]. Moon et al investigated TNF-α mediated anti-cancer therapy mechanism.…”

Section: Phytochemicals Used As Cancer Chemopreventive and Treatmementioning

confidence: 99%

Plants vs. Cancer: A Review on Natural Phytochemicals in Preventing and Treating Cancers and Their Druggability

Wang

Khor²,

Shu³

et al. 2012

ACAMC

490

288

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Cancer remains to be one of the leading causes of death in the United States and around the world. The advent of modern drug-targeted therapies has undeniably improved cancer patients’ cares. However, advanced metastasized cancer remains untreatable. Hence, continued searching for a safer and more effective chemoprevention and treatment is clearly needed for the improvement of the efficiency and to lower the treatment cost for cancer care. Cancer chemoprevention with natural phytochemical compounds is an emerging strategy to prevent, impede, delay, or cure cancer. This review summarizes the latest research in cancer chemoprevention and treatment using the bioactive components from natural plants. Relevant molecular mechanisms involved in the pharmacological effects of these phytochemicals are discussed. Pharmaceutical developmental challenges and opportunities in bringing the phytochemicals into the market are also explored. The authors wish to expand this research area not only for their scientific soundness, but also for their potential druggability.

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Section: Phytochemicals Used As Cancer Chemopreventive and Treatmementioning

confidence: 99%

Plants vs. Cancer: A Review on Natural Phytochemicals in Preventing and Treating Cancers and Their Druggability

Wang

Khor²,

Shu³

et al. 2012

ACAMC

490

288

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“…Total RNA was extracted using TRIzol (Life Technologies Inc.). First-strand cDNA was synthesized from the total RNA with an oligo (dT) [12][13][14][15][16][17][18] primer and ReverTra Ace reverse transcriptase (ToYoBo, Tokyo, Japan) and then subjected to PCR amplification with Ex Taq polymerase (Takara Biochemicals, Tokyo, Japan). PCR products were separated by electrophoresis in 2% agarose gels and visualized by ethidium bromide staining under UV light.…”

Section: Rt-pcr and Real-time Pcrmentioning

confidence: 99%

Rosmarinic acid exerts an antiosteoporotic effect in the RANKL-induced mouse model of bone loss by promotion of osteoblastic differentiation and inhibition of osteoclastic differentiation

Lee

Asai

Jeon

et al. 2015

Mol. Nutr. Food Res.

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“…Recent studies have revealed important new insights into the mechanism of RA action (Lee et al, 2006;Fallarini et al, 2009;Moon et al, 2010;Xu et al, 2010). RA has been reported to inhibit TNF-α-induced activation of the transcription factor NF-κB in human dermal fibroblasts (Lee et al, 2006) and to inhibit NF-κB translocation in SH-SY5Y cells (Fallarini et al, 2009).…”

Section: Ra In Tnf-α-induced Nf-κb Activation: a Key Mechanism Of Actmentioning

confidence: 99%

Rosmarinic acid and its derivatives: biotechnology and applications

Bulgakov

Inyushkina

Fedoreyev

2011

Critical Reviews in Biotechnology

140

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Rosmarinic acid (RA) is one of the first secondary metabolites produced in plant cell cultures in extremely high yields, up to 19% of the cell dry weight. More complex derivatives of RA, such as rabdosiin and lithospermic acid B, later were also obtained in cell cultures at high yields. RA and its derivatives possess promising biological activities, such as improvement of cognitive performance, prevention of the development of Alzheimer's disease, cardioprotective effects, reduction of the severity of kidney diseases and cancer chemoprevention. The TNF-α-induced NF-κB signaling pathway has emerged as a central target for RA. Despite these impressive activities and high yields, the biotechnological production of these metabolites on an industrial scale has not progressed. We summarized data suggesting that external stimuli, the Ca(2+)-dependent NADPH oxidase pathway and processes of protein phosphorylation/dephosphorylation are involved in the regulation of biosynthesis of these substances in cultured plant cells. In spite of growing information about pathways regulating biosynthesis of RA and its derivatives in cultured plant cells, the exact mechanism of regulation remains unknown. We suggest that further progress in the biotechnology of RA and its derivatives can be achieved by using new high-throughput techniques.

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Inhibition of Bone Metastasis from Breast Carcinoma by Rosmarinic Acid

Cited by 64 publications

References 29 publications

Plants vs. Cancer: A Review on Natural Phytochemicals in Preventing and Treating Cancers and Their Druggability

Plants vs. Cancer: A Review on Natural Phytochemicals in Preventing and Treating Cancers and Their Druggability

Rosmarinic acid exerts an antiosteoporotic effect in the RANKL-induced mouse model of bone loss by promotion of osteoblastic differentiation and inhibition of osteoclastic differentiation

Rosmarinic acid and its derivatives: biotechnology and applications

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