“…IGFBP-6 is expressed in many cell types, such as fibroblasts, myoblasts, smooth muscle cells, keratinocytes, and osteoblasts (Yan et al, 2001;Strohbach et al, 2008). Because of its binding preference, IGFBP-6 might regulate IGF-II-induced cell proliferation, differentiation, and survival (Bach et al, 1994;Dake et al, 2002;Kim et al, 2002;Gallicchio et al, 2003;Fu et al, 2007). Generally, IGFBPs play an IGF-dependent role in high affinity IGF binding.…”