Inhibition of cancer cell growth by ruthenium(II) cyclopentadienyl derivative complexes with heteroaromatic ligands

Garcia, M. Helena; Morais, Tânia S.; Florindo, Pedro; Piedade, M. Fátima M.; Moreno, Virtudes; Ciudad, Carlos J.; Noé, Verónique

doi:10.1016/j.jinorgbio.2008.11.016

Cited by 71 publications

(11 citation statements)

References 44 publications

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“…Among the organoruthenium(II) compounds, the half-sandwich organometallic ruthenium compounds with η 6 -arene [ 53 ] or η 5 -cyclopentadienyl [ 54 , 55 , 56 ] exhibited attracting pharmacological properties to be applied in cancer therapy. In these cases, the aromatic ligand present in the structure of the half sandwich compounds allows the stability and protection of the metal Ru(II) [ 57 , 58 ].…”

Section: Introductionmentioning

confidence: 99%

Poly(alkylidenimine) Dendrimers Functionalized with the Organometallic Moiety [Ru(η5-C5H5)(PPh3)2]+ as Promising Drugs Against Cisplatin-Resistant Cancer Cells and Human Mesenchymal Stem Cells

et al. 2018

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Here and for the first time, we show that the organometallic compound [Ru(η5-C5H5)(PPh3)2Cl] (RuCp) has potential to be used as a metallodrug in anticancer therapy, and further present a new approach for the cellular delivery of the [Ru(η5-C5H5)(PPh3)2]+ fragment via coordination on the periphery of low-generation poly(alkylidenimine) dendrimers through nitrile terminal groups. Importantly, both the RuCp and the dendrimers functionalized with [Ru(η5-C5H5)(PPh3)2]+ fragments present remarkable toxicity towards a wide set of cancer cells (Caco-2, MCF-7, CAL-72, and A2780 cells), including cisplatin-resistant human ovarian carcinoma cell lines (A2780cisR cells). Also, RuCp and the prepared metallodendrimers are active against human mesenchymal stem cells (hMSCs), which are often found in the tumor microenvironment where they seem to play a role in tumor progression and drug resistance.

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Section: Introductionmentioning

confidence: 99%

Poly(alkylidenimine) Dendrimers Functionalized with the Organometallic Moiety [Ru(η5-C5H5)(PPh3)2]+ as Promising Drugs Against Cisplatin-Resistant Cancer Cells and Human Mesenchymal Stem Cells

et al. 2018

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“…Our approach in this field has been the study of compounds derived of “RuCp” containing N-heteroaromatic sigma coordinated ligands [23] and CpRu( η 6 -arene) where the structures of the η 6 -arene ligands were based on two or three fused rings [24]. Our studies by AFM revealed a strong interaction with the plasmid pBR322 DNA.…”

Section: Introductionmentioning

confidence: 99%

“…The compound 4 gave a lower IC 50 value than cisplatin at 24 hours and a similar value at 72 hours. Moreover, some other CpRu compounds previously studied showed also significant effect of toxicity in Lovo and MiaPaCa cells in the nanomolar range [23]. …”

Section: Introductionmentioning

confidence: 99%

Studies of the Antiproliferative Activity of Ruthenium (II) Cyclopentadienyl‐Derived Complexes with Nitrogen Coordinated Ligands

Moreno

Lorenzo

Aviles

et al. 2010

Bioinorganic Chemistry and Applications

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Four cationic ruthenium(II) complexes with the formula [Ru(η 5-C5H5)(PPh3)2]+, with L = 5-phenyl-1H-tetrazole (TzH) 1, imidazole (ImH) 2, benzo[1,2-b;4,3-b′] dithio-phen-2-carbonitrile (Bzt) 3, and [5-(2-thiophen-2-yl)-vinyl]-thiophene-2-carbonitrile] (Tvt) 4 were prepared and characterized in view to evaluate their potentialities as antitumor agents. Studies by Circular Dichroism indicated changes in the secondary structure of ct-DNA. Changes in the tertiary structure of pBR322 plasmid DNA were also observed in gel electrophoresis experiment and the images obtained by atomic force microscopy (AFM) suggest strong interaction with pBR322 plasmid DNA; the observed decreasing of the viscosity with time indicates that the complexes do not intercalate between DNA base pairs. Compounds 1, 2, and 3 showed much higher cytotoxicity than the cisplatin against human leukaemia cancer cells (HL-60 cells).

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“…148 The ruthenium complexes commonly used for the biomedical applications are ruthenium-ligand coordination complexes or half-ruthenocenes. 149 …”

Section: Metal-containing Polymeric Drugs and Biocidesmentioning

confidence: 99%

“…20). 149 They synthesized D -glucose end-capped polylactide ruthenocenium cyclopentadienyl complex (compound 1 in Fig. 20).…”

Section: Metal-containing Polymeric Drugs and Biocidesmentioning

confidence: 99%

Metal-containing and related polymers for biomedical applications

et al. 2016

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A survey of the most recent progress in the biomedical applications of metal-containing polymers is given. Due to the unique optical, electrochemical, and magnetic properties, at least 30 different metal elements, most of them transition metals, are introduced into polymeric frameworks for interactions with biology-relevant substrates via various means. Inspired by the advance of metal-containing small molecular drugs and promoted by the great progess in polymer chemistry, metal-containing polymers have gained momentum during recent decades. According to their different applications, this review summarizes the following biomedical applications: 1) metal-containing polymers as drug delivery vehicles; 2) metal-containing polymeric drugs and biocides, including antimicrobial and antiviral agents, anticancer drugs, photodynamic therapy agents, radiotherapy and biocide; 3) metal-containing polymers as biosensors, and 4) metal-containing polymers in bioimaging.

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Inhibition of cancer cell growth by ruthenium(II) cyclopentadienyl derivative complexes with heteroaromatic ligands

Cited by 71 publications

References 44 publications

Poly(alkylidenimine) Dendrimers Functionalized with the Organometallic Moiety [Ru(η5-C5H5)(PPh3)2]+ as Promising Drugs Against Cisplatin-Resistant Cancer Cells and Human Mesenchymal Stem Cells

Poly(alkylidenimine) Dendrimers Functionalized with the Organometallic Moiety [Ru(η5-C5H5)(PPh3)2]+ as Promising Drugs Against Cisplatin-Resistant Cancer Cells and Human Mesenchymal Stem Cells

Studies of the Antiproliferative Activity of Ruthenium (II) Cyclopentadienyl‐Derived Complexes with Nitrogen Coordinated Ligands

Metal-containing and related polymers for biomedical applications

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