Inhibition of Cancer Cell Proliferation by Carbon Dots Derived from Date Pits at Low-Dose

Xie, Yingqiu; Filchakova, Olena; Yesbolatov, Yerkebulan; Tursynkhan, Darkhan; Kassymbek, Aishabibi; Bouhrara, Mohamed; Wang, Kunjie; Balanay, Mannix P.; Fan, Haiyan

doi:10.1002/slct.201700575

Cited by 30 publications

(14 citation statements)

References 44 publications

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“…C‐dots derived from green tea inhibit the growth of MCF‐7, MDAMB‐231 breast cancers, and prostate cancer cells as we and others showed . C‐dots derived from date pits ( Phoenix dactylifera ) inhibit cancerous cell migration with changes in cytoskeleton . Mechanistically, tea derived C‐dots were found to inhibit cancer cell growth and interact with nuclear protein ARF and regulate hippo pathway .…”

Section: Introductionmentioning

confidence: 59%

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Date Pit Carbon Dots Induce Acidic Inhibition of Peroxidase and Disrupt DNA Repair in Antibacteria Resistance

et al. 2019

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Carbon nanodots (C‐dots) are emerging as a new type of promising agent in anticancer, imaging, and new energy. Reports as well as the previous research indicate that certain C‐dots can enhance targeted cancer therapy. However, in‐depth mechanisms for such anticancer effect remain unclear. In this work, treatment provided by the date pit‐derived C‐dots, exhibits significant DNA damage; Annexin V/7‐AAD‐mediated apoptosis, and G2/M cell cycle arrest in prostate cancer cells. The application of C‐dots to the cell generally leads to acidulation of the cell medium, cooperated with membrane compact. The date pit‐derived C‐dots are observed inhibiting the horseradish peroxidase. Moreover, the C‐dots disrupt likely through nucleotide excision DNA repair at low dose during DNA ligation step suggesting the antimicrobial effect and targeting Pim‐1, EGFR, mTOR, and DNA damage pathways in cancer cells. For the first time the detailed and novel mechanisms underlying the C‐dots, derived from the date‐pit, as an efficient, low‐cost, and green nanomaterial are reveled for cancer therapy and anti‐infection.

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Section: Introductionmentioning

confidence: 59%

“…The synthesis and characterization of the date pit‐derived C‐dots were published in the previous work . The fluorescence excitation and emission spectra were measured by a Cary eclipse fluorescence spectrophotometer (Agilent Technologies).…”

Section: Methodsmentioning

confidence: 99%

Date Pit Carbon Dots Induce Acidic Inhibition of Peroxidase and Disrupt DNA Repair in Antibacteria Resistance

et al. 2019

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“…For example, food-derived c-dots have been found to be able to inhibit tumor growth in xenograft model (23). Previously, we found tea-derived c-dots can bind certain amino acids on ARF and colocalize with ARF in nucleus which sensitizes cancer cells to rapamycin (24,25). As the tea leaves derived c-dots are believed mainly contain carbohydrate along with some functional groups such as carbonyl or carboxylic acid, or both, other carbon sources should also be developed into carbon dots and the combination with facial modification through doping may bring some special functions.…”

Section: Introductionmentioning

confidence: 99%

Nuclear MET requires ARF and is inhibited by carbon nanodots through binding to phospho-tyrosine in prostate cancer

Xie

Fan

et al. 2018

Oncogene

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Nuclear receptor tyrosine kinases (nRTKs) are aberrantly upregulated in many types of cancers, but the regulation of nRTK remains unclear. We previously showed androgen deprivation therapy (ADT) induces nMET in castration resistant prostate cancer (CRPC) specimens. Through gene expression microarray profiles reanalysis, we identified that nMET signaling requires ARF in CRPC in vivo Arf deficiency in Pten/Trp53 conditional knockout mouse model. Accordingly, aberrant MET/nMET elevation correlates with ARF in human prostate cancer (PCa) specimens. Mechanistically, ARF elevates nMET through binding to MET cytoplasmic domain to stabilize MET. Furthermore, carbon nanodots resensitize cancer cells to MET inhibitors through DNA damage response. The inhibition of phosphorylation by carbon nanodots was identified through binding to phosphate group of phosphory-tyrosine via computational calculation and experimental assay. Thus nMET is essential to precision therapy of MET inhibitor. Our findings reveal for the first time that targeting nMET axis by carbon nanodots can be a novel avenue for overcoming drug resistance in cancers especially prostate cancer.

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“…Other than the excellent photoluminescent, non-toxic, and biocompatibility properties, CDs also possess a wide range of antimicrobial activity [ 78 ]. Additionally, a study on date pit-derived carbon dots has shown to possess anticancerous effect by inhibiting the growth of human lung cancer, breast cancer (MCF-7), and PC3 cells [ 79 ].…”

Section: Carbon As Scaffold Biomaterials For Sc Applicationsmentioning

confidence: 99%

Modelling of Stem Cells Microenvironment Using Carbon-Based Scaffold for Tissue Engineering Application—A Review

2021

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A scaffold is a crucial biological substitute designed to aid the treatment of damaged tissue caused by trauma and disease. Various scaffolds are developed with different materials, known as biomaterials, and have shown to be a potential tool to facilitate in vitro cell growth, proliferation, and differentiation. Among the materials studied, carbon materials are potential biomaterials that can be used to develop scaffolds for cell growth. Recently, many researchers have attempted to build a scaffold following the origin of the tissue cell by mimicking the pattern of their extracellular matrix (ECM). In addition, extensive studies were performed on the various parameters that could influence cell behaviour. Previous studies have shown that various factors should be considered in scaffold production, including the porosity, pore size, topography, mechanical properties, wettability, and electroconductivity, which are essential in facilitating cellular response on the scaffold. These interferential factors will help determine the appropriate architecture of the carbon-based scaffold, influencing stem cell (SC) response. Hence, this paper reviews the potential of carbon as a biomaterial for scaffold development. This paper also discusses several crucial factors that can influence the feasibility of the carbon-based scaffold architecture in supporting the efficacy and viability of SCs.

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Inhibition of Cancer Cell Proliferation by Carbon Dots Derived from Date Pits at Low-Dose

Cited by 30 publications

References 44 publications

Date Pit Carbon Dots Induce Acidic Inhibition of Peroxidase and Disrupt DNA Repair in Antibacteria Resistance

Date Pit Carbon Dots Induce Acidic Inhibition of Peroxidase and Disrupt DNA Repair in Antibacteria Resistance

Nuclear MET requires ARF and is inhibited by carbon nanodots through binding to phospho-tyrosine in prostate cancer

Modelling of Stem Cells Microenvironment Using Carbon-Based Scaffold for Tissue Engineering Application—A Review

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