2007
DOI: 10.4049/jimmunol.178.8.5296
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Inhibition of CCL1-CCR8 Interaction Prevents Aggregation of Macrophages and Development of Peritoneal Adhesions

Abstract: Peritoneal adhesions are a significant complication of surgery and visceral inflammation; however, the mechanism has not been fully elucidated. The aim of this study was to clarify the mechanism of peritoneal adhesions by focusing on the cell trafficking and immune system in the peritoneal cavity. We investigated the specific recruitment of peritoneal macrophages (PMφ) and their expression of chemokine receptors in murine models of postoperative and postinflammatory peritoneal adhesions. PMφ aggregated at the … Show more

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Cited by 69 publications
(73 citation statements)
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References 39 publications
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“…Statistical power is described as follows: NS, P Ͼ 0.05; *, P Յ 0.05 to P Ն 0.01; **, P Յ 0.01 to P Ն 0.001; and ***, P Ͻ 0.001. is in alignment with observations on multiple sclerosis (MS) lesions from patients who previously has been demonstrated to express CCR8 and correlated with demyelization activity in the brain and in foam cells in arthrosclerosis plaque (16,34). In preclinical models of peritoneal adhesion, macrophages were described to produce CCL1 and respond in an autocrine fashion through CCR8 (17). These cells regulate expression of several adhesion molecules in the integrin family, allowing formation of aggregates of cells that over time result in fibrous tissue (17).…”
Section: Discussionsupporting
confidence: 51%
See 1 more Smart Citation
“…Statistical power is described as follows: NS, P Ͼ 0.05; *, P Յ 0.05 to P Ն 0.01; **, P Յ 0.01 to P Ն 0.001; and ***, P Ͻ 0.001. is in alignment with observations on multiple sclerosis (MS) lesions from patients who previously has been demonstrated to express CCR8 and correlated with demyelization activity in the brain and in foam cells in arthrosclerosis plaque (16,34). In preclinical models of peritoneal adhesion, macrophages were described to produce CCL1 and respond in an autocrine fashion through CCR8 (17). These cells regulate expression of several adhesion molecules in the integrin family, allowing formation of aggregates of cells that over time result in fibrous tissue (17).…”
Section: Discussionsupporting
confidence: 51%
“…In preclinical models of peritoneal adhesion, macrophages were described to produce CCL1 and respond in an autocrine fashion through CCR8 (17). These cells regulate expression of several adhesion molecules in the integrin family, allowing formation of aggregates of cells that over time result in fibrous tissue (17). In context of this observation, it is interesting that adhesion molecule expression on in vitro-generated human M2 macrophages (M-CSF derived) is more sensitive to CCL1 than that on M1 macrophages (GM-CSF derived).…”
Section: Discussionmentioning
confidence: 99%
“…This raises the question whether newly converted Tregs secreting CCL1 play a role in Treg homing and accumulation in the tumor. Paracrine signaling is probable because other immune cells also express CCR8 and migrate to CCL1, cutaneous memory subsets of CD4 + and CD8 + cells (39), NK cells (40,41), Langerhanstype DCs (42), peritoneal macrophages (43), and Th2 cells (44). This evidence of the role of ITGaE and CCL1 in Treg biology led us to investigate these targets further.…”
Section: Discussionmentioning
confidence: 99%
“…The real-time quantitative PCR analyses were performed using the ABI 7700 sequence detector system with SYBR Green (Applied Biosystems, Foster City, CA). The sequences were amplified for 40 cycles under the following conditions: denaturation at 95°C for 15 s, annealing at 60°C for 30 s, and extension at 72°C for 45 s with primers for the chemokine receptors as previously reported (17). Gene expression levels were compared with Gapdh gene expression by the 2 Ϫ⌬(Ct) method.…”
Section: Methodsmentioning
confidence: 99%