Inhibition of CD62L+ T-cell response in vitro via a novel sulfo-glycolipid, β-SQAG9 liposome that binds to CD62L molecule on the cell surface

Yamamoto, Yoshiteru; Sahara, Hiroeki; Takenouchi, Mika; Matsumoto, Yoshitaka; Imai, A.; Fujita, Tatsuya; Tamura, Yasuaki; Takahashi, Nobuaki; Gasa, Shinsei; Matsumoto, Kenjiro; Ohta, Keisuke; Sugawara, Fumio; Sakaguchi, Kengo; Jimbow, Kowichi; Sato, Noriyuki

doi:10.1016/j.cellimm.2005.02.002

Cited by 9 publications

(7 citation statements)

References 40 publications

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“…Liposomes have also been reported to promote the development of T cell-independent B cell immune responses [24] and have potential to promote long-term immunity through the development of T-cell memory [25]. In addition to their innate adjuvanticity, liposomes have been incorporated with a plethora of adjuvants ranging from small molecules [26,27], glycolipids [28][29][30][31], oligodeoxynucleotides [32][33][34][35], to cyclic dinucleotides [6,36].…”

Section: Liposomes and Lipid-based Nanoparticlesmentioning

confidence: 99%

Nanoparticle Vaccines Adopting Virus-like Features for Enhanced Immune Potentiation

et al. 2017

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Synthetic nanoparticles play an increasingly significant role in vaccine design and development as many nanoparticle vaccines show improved safety and efficacy over conventional formulations. These nanoformulations are structurally similar to viruses, which are nanoscale pathogenic organisms that have served as a key selective pressure driving the evolution of our immune system. As a result, mechanisms behind the benefits of nanoparticle vaccines can often find analogue to the interaction dynamics between the immune system and viruses. This review covers the advances in vaccine nanotechnology with a perspective on the advantages of virus mimicry towards immune potentiation. It provides an overview to the different types of nanomaterials utilized for nanoparticle vaccine development, including functionalization strategies that bestow nanoparticles with virus-like features. As understanding of human immunity and vaccine mechanisms continue to evolve, recognizing the fundamental semblance between synthetic nanoparticles and viruses may offer an explanation for the superiority of nanoparticle vaccines over conventional vaccines and may spur new design rationales for future vaccine research. These nanoformulations are poised to provide solutions towards pressing and emerging human diseases.

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Section: Liposomes and Lipid-based Nanoparticlesmentioning

confidence: 99%

Nanoparticle Vaccines Adopting Virus-like Features for Enhanced Immune Potentiation

et al. 2017

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“…[9,10] Furthermore, immunosuppressive attributes of SQDGs have been identified to inhibit selectins. [11,12] In all these processes the fatty acid spectrum can influence the biological effect of SQDGs. [7][8][9][10][11][12] SQDGs have been detected in different eukaryotic microalgae such as Nitzschia alba, [13] Chlamydomonas reinhardtii, [14] Chlorella vulgaris [15] and Porphyridium purpureum.…”

Section: Erlangen 91052 Germanymentioning

confidence: 99%

“…The air supply was adjusted to 1 L/min and enriched with 2.5% CO 2 . Phaedactylum tricornutum strains SAG 1090-1b and 1090-6 were cultivated in brackish water medium [23] 12 ). Phaedactylum tricornutum 1090-1a was cultivated in modified trebon medium [24] (1.0 g/L KNO 3 )).…”

Section: Algae and Growth Conditionsmentioning

confidence: 99%

“…Additionally, biological experiments demonstrated an antineoplastic effect by inhibition of DNA‐polymerases pol α and pol β . Furthermore, immunosuppressive attributes of SQDGs have been identified to inhibit selectins . In all these processes the fatty acid spectrum can influence the biological effect of SQDGs …”

mentioning

confidence: 99%

“…Furthermore, immunosuppressive attributes of SQDGs have been identified to inhibit selectins . In all these processes the fatty acid spectrum can influence the biological effect of SQDGs …”

mentioning

confidence: 99%

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Identification of sulfoquinovosyldiacyglycerides from Phaeodactylum tricornutum by matrix‐assisted laser desorption/ionization QTrap time‐of‐flight hybrid mass spectrometry

Naumann

Klein

Bartel

et al. 2011

Rapid Comm Mass Spectrometry

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The pharmaceutical industry is interested in identifying novel target compounds. Due to their versatile pharmacological activities (e.g. antiviral, anti-carcinogen and immunosuppressive) sulfoquinovosyldiacylglycerides (SQDGs) are potential drug candidates. The present publication deals with the purification and structural characterization of SQDGs from three different strains of Phaeodactylum tricornutum. Besides detection of SQDGs (sn-1: C16:1/sn-2: C16:0 and sn-1: C20:5/sn-2: C16:0), two novel 2'-O-acylsulfoquinovosyldiacylglyerides (Ac-SQDGs, sn-1: C16:0/ sn-2: C16:0/2' C20:5 and sn-1: C20:5/sn-2: C16:0/2' C20:5) were identified by using matrix-assisted laser desorption/ionization (MALDI) QTrap time-of-flight (ToF) hybrid mass spectrometry (MS) with multistage MS(n). The analytical method enables the sn-position verification of fatty acids (MS(2)) as well as the confirmation of the regioposition of eicospentanoic acid at the sulfoquinovose (MS(3)).

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An Emulsion of Sulfoquinovosylacylglycerol with Long-Chain Alkanes Increases Its Permeability to Tumor Cells

et al. 2006

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The alpha-anomer form of sulfoquinovosyl-monoacylglycerol with a saturated C18 fatty acid (alpha-SQMG-C(18:0)) is a natural sulfolipid that is a clinically promising antitumor agent. It forms vesicles, micelles or an emulsion in water, depending on several physicochemical conditions. The type of aggregate formed appears to strongly influence the bioactivity level. Thus, we investigated the nature of the aggregates in relation to their bioactivities. The structure of the alpha-SQMG-C(18:0) assembly was greatly affected by the type of additive used in the preparation. Emulsification with ethanol and n-decane might be more effective at inhibiting tumor cell growth than the micelle or vesicle preparations. alpha-SQMG-C(18:0) formed an "emulsion-like-aggregate" in ethanol containing an n-decane concentration in the range of 1.03-103 mM: . These ethanol/n-alkane/alpha-SQMG-C(18:0) aggregates inhibited cell growth in a dose-dependent manner, under optimum conditions (i.e., ethanol containing 103 mM: of n-decane or n-dodecane dispersed in phosphate-buffered saline or culture medium). Based on these data, we discuss the relationship between the molecular action of and antitumor activity by alpha-SQMG-C(18:0).

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Inhibition of CD62L+ T-cell response in vitro via a novel sulfo-glycolipid, β-SQAG9 liposome that binds to CD62L molecule on the cell surface

Cited by 9 publications

References 40 publications

Nanoparticle Vaccines Adopting Virus-like Features for Enhanced Immune Potentiation

Nanoparticle Vaccines Adopting Virus-like Features for Enhanced Immune Potentiation

Identification of sulfoquinovosyldiacyglycerides from Phaeodactylum tricornutum by matrix‐assisted laser desorption/ionization QTrap time‐of‐flight hybrid mass spectrometry

An Emulsion of Sulfoquinovosylacylglycerol with Long-Chain Alkanes Increases Its Permeability to Tumor Cells

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