Inhibition of cell-cycle progression in HeLa cells by HY52, a novel cyclin-dependent kinase inhibitor isolated from Bauhinia forficata

Lim, Haeyoung; Kim, Min Kyoung; Lim, Yoongho; Cho, Youl-Hee; Lee, Chul-Hoon

doi:10.1016/j.canlet.2005.03.002

Cited by 23 publications

(17 citation statements)

References 19 publications

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“…3B) and the cell cycle of HeLa cells is well characterized. [15][16][17] Our results strongly suggest that CAC1 is a cell cycle associated protein capable of promoting cell proliferation through the activation of CDK2 at the G 1 /S phase transition.…”

Section: Introductionmentioning

confidence: 59%

Identification and characterization of CAC1 as a novel CDK2-associated cullin

Kong

Kang²,

Yin³

2009

Cell Cycle

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Section: Introductionmentioning

confidence: 59%

Identification and characterization of CAC1 as a novel CDK2-associated cullin

Kong

Kang²,

Yin³

2009

Cell Cycle

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“…For example, an in vitro antitumoral activity was described and related to an unusual nitrogenated compound isolated from the leaves (Lim et al, 2006), while Oliveira et al (2005) showed that the aqueous extract from aerial parts of B. forficata was able to neutralize the clotting activity induced by Bothrops and Crotalus crude venoms. This study concluded that the plant extract is also a promising source of natural inhibitors of serine-proteases involved in blood clotting disturbances induced by snake venoms.…”

Section: Bauhinia Forficata Link Fabaceae (Mororó)mentioning

confidence: 99%

Bioactivity and potential therapeutic benefits of some medicinal plants from the Caatinga (semi-arid) vegetation of Northeast Brazil: a review of the literature

Silva¹,

Melo²,

Vasconcelos³

et al. 2012

Rev. bras. farmacogn.

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Abstract:Medicinal plants have been used in traditional medicine for several thousand years all over the world. In this sense, information from Brazilian ethnic groups on folk medicine have contributed to the discovery of pharmacological activities from various plant-derived agents potentially leading to the innovative drugs. The Caatinga (semi-arid) vegetation is a highly threatened biome, covering a vast area in northeastern Brazil and has suffered from strong human influence for many decades. Many plants species found in the Caatinga have been widely used in folk medicine and for commercial manufacturing of phytotherapeutic products. Thus, the present review aims to disseminate to the scientific community some known species of medicinal plants found in the Caatinga that have been studied and analyzed in pharmacological scientific assays. Among the species that stood out for their local importance and multiplicity of uses were: Amburana cearensisand Zingiber officinalis L. (gengibre). The present study shows that several herbal constituents from Caatinga plants, whose pharmacological actions have been well characterized, may be relevant candidates for future and innovative therapeutic development.

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“…The HY52 substance, which as isolated from the leaves of this plant, inhibits the growth of cervical adenocarcinoma cells (IC50 0.11 µM) and induces apoptosis by promoting cell cycle arrest at the G1 phase (Lim et al, 2006).…”

Section: Bauhinia Forficata Link Fabaceaementioning

confidence: 99%

Phytochemical and pharmacological notes of plants indicated to treat tumors in Brazil

Melo¹,

Santos²,

Amorim³

et al. 2011

Rev. bras. farmacogn.

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Abstract:The plants used in traditional medicine have been considered an important source of molecules with pharmacological activity, including antitumor. The aim of this study was to present a pharmacological description and the phytochemical components related to antitumor activity of thirty plants commonly cited in Brazil to treat tumors as well as offering an overview of approaches that are necessary for the development of herbal medicines from these resources. In the search for studies with these plants, fi ve database were used (SciELO, Scirus, Scopus, Biological Abstracts and Web of Science), with the following keywords: tumor AND Species AND cancer. We consider all the scientifi c synonyms of species available in the Tropicos ® database (http://www.tropicos. org/). We surveyed papers from the period between 1980 and 2008. Twnety one species (70%) have at least one evaluation of a class of molecule or metabolite isolated against a pharmacological model. Most species (60%) has in vivo studies. Of the thirty plant species, two stood out for having pharmacological studies in vitro, in vivo and clinical with positive results: Chelidonium majus L., Papaveraceae, and Aloe arborescens Mill., Xanthorrhoeaceae. Although there is generally a good activity of species presented here, there is a need for further studies in order to evaluate the possibility of developing some byproduct.

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Inhibition of cell-cycle progression in HeLa cells by HY52, a novel cyclin-dependent kinase inhibitor isolated from Bauhinia forficata

Cited by 23 publications

References 19 publications

Identification and characterization of CAC1 as a novel CDK2-associated cullin

Identification and characterization of CAC1 as a novel CDK2-associated cullin

Bioactivity and potential therapeutic benefits of some medicinal plants from the Caatinga (semi-arid) vegetation of Northeast Brazil: a review of the literature

Phytochemical and pharmacological notes of plants indicated to treat tumors in Brazil

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