Inhibition of cell proliferation by azolium salts and silver(I)-N-heterocyclic carbene complexes: Synthesis, spectral and X-ray crystallographic characterizations

Hayat, Khizar; Shkeel, Mahwish; Iqbal, Muhammad Adnan; Khalid, Maria; Quah, Ching Kheng; Wong, Qin Ai; Rehman, Ateeq Ur; Ahamed, Mohd. B. Khadeer; Hameed, Shahid

doi:10.1016/j.ica.2023.121694

Cited by 5 publications

(2 citation statements)

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“…The high stability of Ag(I)‐NHC complexes means that silver ions are released more slowly, making them therapeutically effective for longer periods [6,39–43] . The selection of metals in biological systems is crucial, and new silver(I)‐NHC complexes were synthesized and tested against various carcinoma cell lines, following the initial report of the cytotoxic activity of silver(I)‐NHC complex against breast cancer (MCF‐7), cervical cancer (HeLa), and colon adenocarcinoma (HCT 116) [16–17,41,44‐47] .…”

Section: Introductionmentioning

confidence: 99%

“…[33][34][35][36][37][38] The high stability of Ag(I)-NHC complexes means that silver ions are released more slowly, making them therapeutically effective for longer periods. [6,[39][40][41][42][43] The selection of metals in biological systems is crucial, and new silver(I)-NHC complexes were synthesized and tested against various carcinoma cell lines, following the initial report of the cytotoxic activity of silver(I)-NHC complex against breast cancer (MCF-7), cervical cancer (HeLa), and colon adenocarcinoma (HCT 116). [16][17]41,[44][45][46][47] Furthermore, the new Ag(I)-NHC complexes have been employed in a range of catalytic reactions, such as cross-coupling reactions, CÀ H activation, and asymmetric transformations.…”

Section: Introductionmentioning

confidence: 99%

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Synthesis and Anticancer Activities of some Ag(I) Complexes Involving N‐Heterocyclic Carbene Ligands

Mageed,

Hadi

2024

ChemistrySelect

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A new study focused on the synthesis of silver(I)‐N‐heterocyclic carbene complexes. The mono‐Ag(I)‐NHC complexes were successfully synthesized in high yield using a direct complexation method, which involved an excess of Ag2O and imidazolium salts (R= butyl, methylacetate) in dichloromethane. The bis‐Ag(I)‐NHC complexes, on the other hand, were synthesized using a 1 : 2 ratio of Ag2O and imidazolium salts. The ligands and resulting complexes were thoroughly characterized using analytical techniques such as FT‐IR, NMR spectroscopy, LC–MS and elemental analysis. Subsequently, the synthesized complexes were tested against MCF7 breast cancer cells. The results of the study highlighted the remarkable anticancer potential exhibited by the Ag(I)‐NHC complexes against breast cancer cells. Interestingly, it was observed that the mono Ag(I) NHC complexes demonstrated greater potency, with IC50 values ranging from 5 to 13.5 μg/mL, when compared to their bis‐Ag(I)‐NHC counterparts.

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Section: Introductionmentioning

confidence: 99%