Inhibition of cerebral metabolic and circulatory responses to nitrous oxide by 6-hydroxydopamine in dogs

Abstract

Purpose: To determine whether cerebral metabolic and circulatory consequences of N20 result from activation of the sympathoadrenal system. The effects of pretreatment with intradstemal injection of 6-OHDA, which produces chemical sympathectomy, were studied in dogs.

Interactions between Nitrous Oxide and Tissue Plasminogen Activator in a Rat Model of Thromboembolic Stroke

“…29 Difference between the effects of postischemic xenon and postischemic nitrous oxide on tPA-induced brain hemorrhages and disruption of the blood-brain barrier are likely to occur at the vascular, rather than the parenchymal, level. This could be because xenon has no effect or even decreases cerebral blood flow in specific brain regions at concentrations to 1 minimum anesthetic concentration, [45][46][47] whereas in contrast, nitrous oxide at concentrations as low as 0.5 minimum anesthetic concentration is well known to increase cerebral blood flow and cerebral blood flow velocity, 48,49 conditions that could favor disruption of the blood-brain barrier, particularly during reperfusion.…”

The effect of nitrous oxide on cerebral blood flow velocity in children anesthetized with propofol

“…In children, nitrous oxide has been shown to increase Vmca during a balanced anesthetic technique (11) and causes cerebral excitation and an increase in CMRO 2 (14). Although the exact mechanism is not known, sympathoadrenal stimulation (20, 21), and mitochondrial activation (14, 22), have been postulated. Using contrast‐enhanced magnetic resonance perfusion measurements, Lorenz et al (23) demonstrated an increase in regional cerebral blood flow and volume with nitrous oxide.…”

Global and regional brain metabolic scaling and its functional consequences

“…Glucose utilization data were taken from the following sources for: mouse [65,66]; rat [67-73]; rabbit [74]; squirrel [75]; cat [76-80]; macaque monkey [81-84]; baboon [85]; goat [86]; sheep [87] (both glucose and oxygen); human [5,88-93]. Oxygen consumption data were taken from the following sources for: rat [94]; cat [95]; dog [96]; macaque monkey [97]; baboon [98]; human [5,99]. …”