2006
DOI: 10.1089/scd.2006.15.647
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Inhibition of cGMP-Dependent Protein Kinase Reduces the Response to Sonic Hedgehog in Neuralized Embryoid Bodies

Abstract: Previously, we have shown that increasing the intracellular cGMP concentration enhances the sonic hedgehog (Shh) response in neural plate cells. The use of two mouse embryonic stem (ES) cell lines allowed a highly sensitive and reproducible quantification of the Shh response in neuralized embryoid bodies. Here we demonstrate that the specific, membrane-permeable cGMP-dependent protein kinase G-Ialpha (PKG-Ialpha) inhibitor DT-2 prevents an efficient Shh response, indicating that the effects of cGMP on the Shh … Show more

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Cited by 4 publications
(1 citation statement)
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“…In mammalian two PKG genes have been identified, encoding for PGK-I and PGK-II. Upon cGMP stimulation PKG-I has been shown to mediate the response to HH signaling in neural plate cells and in embryoid bodies [131,132]. The effect of cGMP/PKG on HH pathway is opposite to that of cAMP and PKA.…”
Section: The Major Phosphorylation Events In Hedgehog Pathway: Thementioning
confidence: 99%
“…In mammalian two PKG genes have been identified, encoding for PGK-I and PGK-II. Upon cGMP stimulation PKG-I has been shown to mediate the response to HH signaling in neural plate cells and in embryoid bodies [131,132]. The effect of cGMP/PKG on HH pathway is opposite to that of cAMP and PKA.…”
Section: The Major Phosphorylation Events In Hedgehog Pathway: Thementioning
confidence: 99%