2005
DOI: 10.1016/j.jpain.2004.12.003
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Inhibition of chemical and low-intensity mechanical nociception by activation of histamine H3 receptors

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Cited by 47 publications
(29 citation statements)
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“…Because systemically administered immepip was effective against mechanical nociception in rats, Cannon et al (2003) suggested the possibility of a species difference in the spinal penetration by immepip, but several explanations seem possible for the discrepancy. A subsequent detailed evaluation with a wide variety of nociceptive stimuli in rats confirmed that the acute antinociceptive profile of H 3 agonists is both modality-specific (i.e., mechanical versus thermal) and intensity-specific (low versus high mechanical) (Cannon and Hough, 2005). Collectively, the studies show that low-intensity mechanical nociception is attenuated by activation of spinal H 3 Rs (Cannon et al, 2003;Cannon and Hough, 2005).…”
Section: Peripheral H 3 Rs and Inflammationmentioning
confidence: 73%
See 1 more Smart Citation
“…Because systemically administered immepip was effective against mechanical nociception in rats, Cannon et al (2003) suggested the possibility of a species difference in the spinal penetration by immepip, but several explanations seem possible for the discrepancy. A subsequent detailed evaluation with a wide variety of nociceptive stimuli in rats confirmed that the acute antinociceptive profile of H 3 agonists is both modality-specific (i.e., mechanical versus thermal) and intensity-specific (low versus high mechanical) (Cannon and Hough, 2005). Collectively, the studies show that low-intensity mechanical nociception is attenuated by activation of spinal H 3 Rs (Cannon et al, 2003;Cannon and Hough, 2005).…”
Section: Peripheral H 3 Rs and Inflammationmentioning
confidence: 73%
“…A subsequent detailed evaluation with a wide variety of nociceptive stimuli in rats confirmed that the acute antinociceptive profile of H 3 agonists is both modality-specific (i.e., mechanical versus thermal) and intensity-specific (low versus high mechanical) (Cannon and Hough, 2005). Collectively, the studies show that low-intensity mechanical nociception is attenuated by activation of spinal H 3 Rs (Cannon et al, 2003;Cannon and Hough, 2005). Because 1) specific types of H 3 Rcontaining peripheral afferent fibers project to the dorsal horn, and 2) dorsal horn neurons have limited expression of H 3 R message (Héron et al, 2001) and H 3 RLI (Cannon et al, 2007a), it was suggested that the antinociceptive effects of intrathecal H 3 agonists are mediated by inhibition of transmitter release from afferent fibers in the spinal cord, a presynaptic effect (Cannon et al, 2003).…”
Section: Peripheral H 3 Rs and Inflammationmentioning
confidence: 84%
“…Thioperamide shows antinociceptive efficacy in various models of acute pain and also attenuates morphine-induced analgesia. 272,273) Opposing effects are observed in a model of neuropathic pain, depending on whether the compound is administered centrally or peripherally. 274) Moreover, as thioperamide also shows affinity on H 4 R 54,275) the exclusive blockade of H 3 R is requested to evaluate an effect of H 3 R antagonists on neuropathic pain.…”
Section: )mentioning
confidence: 99%
“…H 3 R activation in the CNS results in lower hypothalamic histamine release, and an H 3 R agonist may be used to treat insomnia [109]. In addition, Hough and coworkers revealed an antinociceptive role for spinal histamine H 3 R [110]. In the past years, several studies have hinted at a role of the H 3 R in neuroprotection.…”
Section: Characteristics Of the H 3 Rmentioning
confidence: 99%