Inhibition of chloroplast translation as a new target for herbicides

Sukhoverkov, Kirill V.; Breese, Karen J.; Debowski, Aleksandra W.; Murcha, Monika W.; Stubbs, Keith A.; Mylne, Joshua S.

doi:10.1039/d1cb00192b

Cited by 6 publications

(2 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the 1950s and 1980s, novel MOA herbicides were developed, steadily increasing every two years . However, in the last 40 years, only homogentisate solanesyltransferase (HST) inhibitor cyclopyimorate, dihydroorotate dehydrogenase (DHODH) inhibitor tetflupyrolimet, and chloroplast protein translation inhibitor were discovered as commercialized novel MOA herbicides. − Therefore, the study of herbicide MOA and the discovery of new targets are very challenging and economically and environmentally significant research fields.…”

Section: Introductionmentioning

confidence: 99%

Herbicidal Active Compound Ferulic Acid Ethyl Ester Affects Fatty Acid Synthesis by Targeting the 3-Ketoacyl-Acyl Carrier Protein Synthase I (KAS I)

Jia

et al. 2023

J. Agric. Food Chem.

View full text Add to dashboard Cite

Exploring new herbicide targets based on natural product derivatives is an important research aspect for the generation of innovative pesticides. Ferulic acid ethyl ester (FAEE), a natural product derivative from ferulic acid, has significant herbicidal activity mainly by inhibiting the normal growth of weed seedling roots. However, the FAEE target protein underlying its herbicidal activity has not been identified. In this study, we synthesized an FAEE probe to locate its site of action. We discovered that FAEE entry point was via the root tips. Fourteen major binding proteins were identified using Drug affinity responsive target stability (DARTS) combined with LC-MS/MS, which included 3-ketoacyl-acyl carrier protein synthase I (KAS I) and phenylalanine ammonia-lyase I (PAL I). The KAS I and PAL I proteins/genes expression was changed significantly after exposure to FAEE, as evidenced by combined transcriptomic and proteomic analysis. A molecular docking assay indicated that KAS I and FAEE had a strong binding ability. Combined with previous studies on FAEE mechanism of action, and based on our results, we conclude that FAEE targeting KAS I lead to the blockage of the fatty acid synthesis pathway and result in plant death.

show abstract

Section: Introductionmentioning

confidence: 99%

Herbicidal Active Compound Ferulic Acid Ethyl Ester Affects Fatty Acid Synthesis by Targeting the 3-Ketoacyl-Acyl Carrier Protein Synthase I (KAS I)

Jia

et al. 2023

J. Agric. Food Chem.

View full text Add to dashboard Cite

show abstract

“…2-Oxazolidinones are important five-membered nitrogen heterocyclic compounds that are widely used as pesticides, herbicides, chiral auxiliaries, and pharmaceutical intermediates . Many 2-oxazolidinones with specific structures are commercially available drugs, such as Linezolid (antibiotic drugs used to treat drug-resistant bacterial infections), Torezolid (antibiotic drugs used to treat adult skin infections), and Zolmitriptan (receptor agonist used for the treatment of acute migraine) (Figure ).…”

mentioning

confidence: 99%

Electrochemically Mediated Carboxylative Cyclization of Allylic/Homoallylic Amines with CO₂ at Ambient Pressure

et al. 2022

View full text Add to dashboard Cite

CO 2 is an important C1 resource. We report a method for the synthesis of pharmacologically active 2oxazolidinones by reacting CO 2 with allylic amines. As opposed to previous addition reactions, the unsaturated double bonds are preserved. Thus, the product is more plastic and easier to use for subsequent structural modification. Furthermore, this method can also be applied to the synthesis of six-membered heterocycles (1,3oxazinan-2-ones) and the participation of a low concentration of CO 2 , indicating it has certain practicability.

show abstract

Chloroplast Translation Machinery

Lokdarshi

2024

Nucleic Acids and Molecular Biology

View full text Add to dashboard Cite

Inhibition of chloroplast translation as a new target for herbicides

Abstract: The antibiotic linezolid is an effective herbicide pre- and post-emergence. Making a series of analogues, we partly separated its antibacterial and herbicidal activities, making chloroplast translation a potential new herbicide mode of action.

Cited by 6 publications

References 47 publications

Herbicidal Active Compound Ferulic Acid Ethyl Ester Affects Fatty Acid Synthesis by Targeting the 3-Ketoacyl-Acyl Carrier Protein Synthase I (KAS I)

Herbicidal Active Compound Ferulic Acid Ethyl Ester Affects Fatty Acid Synthesis by Targeting the 3-Ketoacyl-Acyl Carrier Protein Synthase I (KAS I)

Electrochemically Mediated Carboxylative Cyclization of Allylic/Homoallylic Amines with CO₂ at Ambient Pressure

Chloroplast Translation Machinery

Contact Info

Product

Resources

About

Inhibition of chloroplast translation as a new target for herbicides

Abstract: The antibiotic linezolid is an effective herbicide pre- and post-emergence. Making a series of analogues, we partly separated its antibacterial and herbicidal activities, making chloroplast translation a potential new herbicide mode of action.

Cited by 6 publications

References 47 publications

Herbicidal Active Compound Ferulic Acid Ethyl Ester Affects Fatty Acid Synthesis by Targeting the 3-Ketoacyl-Acyl Carrier Protein Synthase I (KAS I)

Herbicidal Active Compound Ferulic Acid Ethyl Ester Affects Fatty Acid Synthesis by Targeting the 3-Ketoacyl-Acyl Carrier Protein Synthase I (KAS I)

Electrochemically Mediated Carboxylative Cyclization of Allylic/Homoallylic Amines with CO2 at Ambient Pressure

Chloroplast Translation Machinery

Contact Info

Product

Resources

About

Electrochemically Mediated Carboxylative Cyclization of Allylic/Homoallylic Amines with CO₂ at Ambient Pressure