Inhibition of cholesterol synthesis in vitro by extracts and isolated compounds prepared from garlic and wild garlic

Sendl, A.; Schliack, M.; Löser, R.; Stanislaus, F; Wagner, Hildebert

doi:10.1016/0021-9150(92)90190-r

Cited by 81 publications

(32 citation statements)

References 21 publications

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“…In vitro studies using isolated rodent and human hepatocytes have demonstrated that garlic inhibits cholesterol synthesis in a dosedependent manner without significant toxicity [105][106][107]. Work by Gebhardt et al suggests that the reduction in cholesterol synthesis occurs at the level of HMG-CoA reductase, but at higher doses lanosterol and 7-dehydrocholesterol will accumulate, suggesting effects further downstream in the cholesterol synthesis pathway [106].…”

Section: Garlicmentioning

confidence: 96%

Dietary Supplements for Cholesterol Management

Almandoz

2015

Contemporary Endocrinology

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Section: Garlicmentioning

confidence: 96%

Dietary Supplements for Cholesterol Management

Almandoz

2015

Contemporary Endocrinology

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“…12) These studies suggested that allyl compounds in these vegetables would play an important role in the expression of their physiological activity.IO.12) The comparative potential of constituents present in these vegetables is under Imres'tlg;atlIDn.…”

Section: --~----------------~-~---mentioning

confidence: 99%

Effect of Vegetable Extracts on Immunoglobulin Production by Mesenteric Lymph Node Lymphocytes of Sprague-Dawley Rats

Kaku

Yamada

Hassan

et al. 1997

Bioscience, Biotechnology, and Biochemistry

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“…They have been suggested to be hypolipidemic, hypoglycemic, anticoagulant, antihypertensive, antimicrobial, anticancer, antitumor, hepatoprotective, immunomodulator and as an antidote for heavy metal poisoning (Lawson, 1994). They possesses significant antioxidant effects because of their content of organo-sulfur compounds such as ajoene, alliine and allicin (Block, 1985;Focke et al, 1990;Sendl et al, 1992).their effect on the mineral bioavailability have been tested because of their antioxidant effect that protect some important mineral against the oxidative damage and also prevent the oxidation of some important fatty acids that enhance the mineral bioavailability (Chatty et al, 2004). These fatty acids are divided into two categories n-3 and n-6, they can originate from α-linolenic acid and linoleic acid respectively.…”

Section: Introductionmentioning

confidence: 99%

Effect of dietary garlic and onion on liver and tibial mineral concentrations in omega-3 fatty acids rich oil fed rats

Mohamed¹,

Kader²

2011

ABJNA

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This study was designed to compare the effect of garlic or onion (2%) on mineral concentrations in liver and tibia of rats fed with diet rich in omega-3 fatty acids. Experiments were carried out on Male Sprague-Dawley rats fed AIN93 semi-purified diets containing either 8 % flaxseed or olive oils replacing corn oil with or without garlic or onion (2%) for 28 days. The analysis of minerals calcium (Ca), phosphorous (P), potassium (K), magnesium (Mg), sodium (Na), iron (Fe) and zinc (Zn) of liver and tibia were conducted by the Atomic Absorption Spectrophotometer. The results showed significantly increased Zn, Mg and P concentrations in liver and K, Na and P in tibia of rats fed on flaxseed oil diet, compared to rats fed on olive oil diet. While the liver Fe and K as well as tibial Ca and Mg were significantly decreased. The addition of garlic powder (2%) to the olive oil diet produced a marked increase in liver Ca, Zn, K, Mg and P levels .However, there was noticeable reduction in liver Fe and tibial Ca and Na levels. No change in tibial Zn level was found by the addition of either garlic or onion powders (2%) to the olive oil diet. Liver of rats fed on olive oil diet with onion powder (2%) have noticeable elevation in Zn, Mg and P and reduction in Fe and K levels. There was a significant decrease in tibial Ca and Na levels, compared to rats fed on olive oil control diet. Flaxseed oil diet with garlic powders (2%) led to a significant increase in liver P and tibial Mg concentrations. Although a marked reduce was observed in liver Na and tibial Ca, Zn, Na and P levels. The same addition to the same diet caused a non significant decrease in liver Zn and Na as well as tibial Ca, Fe and Zn concentrations. The addition of onion powder (2%) to flaxseed oil diet produced a noticeable increase in liver Fe, k and P levels as well as tibial Mg level. Meanwhile, no marked increase was found in liver Ca, Zn and Na levels and decrease in liver Mg and tibial Fe. A significant decrease was found in tibial Ca, Zn, Na and P concentrations. In conclusion: the present study concluded that adding garlic or onion to diet rich in mono or poly unsaturated fatty acids elevate the levels of some minerals in liver and tibia of rats, Which contributes to the maintenance of the health status of the liver and bone.

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Inhibition of cholesterol synthesis in vitro by extracts and isolated compounds prepared from garlic and wild garlic

Cited by 81 publications

References 21 publications

Dietary Supplements for Cholesterol Management

Dietary Supplements for Cholesterol Management

Effect of Vegetable Extracts on Immunoglobulin Production by Mesenteric Lymph Node Lymphocytes of Sprague-Dawley Rats

Effect of dietary garlic and onion on liver and tibial mineral concentrations in omega-3 fatty acids rich oil fed rats

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