Inhibition of CISD1 alleviates mitochondrial dysfunction and ferroptosis in mice with acute lung injury

Zhang, Xueli; Peng, Tian; Li, Congying; Ai, Chenmu; Wang, Xiang; Lei, Xiaobao; Li, Guicheng; Li, Tao

doi:10.1016/j.intimp.2024.111685

Cited by 6 publications

(1 citation statement)

References 29 publications

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“…et al, 2022 ). Inhibition of CISD1 reduced LPS-induced ferroptosis in vivo and in vitro by preventing mitochondrial membrane potential depolarization, cellular ATP reduction, and ROS accumulation ( Zhang et al, 2024 ). CISD1-Dependent regulation of ferroptosis is shown in glutathione depletion–induced oxidative cardiomyopathy in murine hearts ( Li et al, 2024 ).…”

Section: Protective Pathways and Novel Therapeutic Targets Against Fe...mentioning

confidence: 99%

A critical appraisal of ferroptosis in Alzheimer’s and Parkinson’s disease: new insights into emerging mechanisms and therapeutic targets

Soni,

Ammal Kaidery,

Sharma

et al. 2024

Front. Pharmacol.

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Neurodegenerative diseases represent a pressing global health challenge, and the identification of novel mechanisms underlying their pathogenesis is of utmost importance. Ferroptosis, a non-apoptotic form of regulated cell death characterized by iron-dependent lipid peroxidation, has emerged as a pivotal player in the pathogenesis of neurodegenerative diseases. This review delves into the discovery of ferroptosis, the critical players involved, and their intricate role in the underlying mechanisms of neurodegeneration, with an emphasis on Alzheimer’s and Parkinson’s diseases. We critically appraise unsolved mechanistic links involved in the initiation and propagation of ferroptosis, such as a signaling cascade resulting in the de-repression of lipoxygenase translation and the role played by mitochondrial voltage-dependent anionic channels in iron homeostasis. Particular attention is given to the dual role of heme oxygenase in ferroptosis, which may be linked to the non-specific activity of P450 reductase in the endoplasmic reticulum. Despite the limited knowledge of ferroptosis initiation and progression in neurodegeneration, Nrf2/Bach1 target genes have emerged as crucial defenders in anti-ferroptotic pathways. The activation of Nrf2 and the inhibition of Bach1 can counteract ferroptosis and present a promising avenue for future therapeutic interventions targeting ferroptosis in neurodegenerative diseases.

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Section: Protective Pathways and Novel Therapeutic Targets Against Fe...mentioning

confidence: 99%

A critical appraisal of ferroptosis in Alzheimer’s and Parkinson’s disease: new insights into emerging mechanisms and therapeutic targets

Soni,

Ammal Kaidery,

Sharma

et al. 2024

Front. Pharmacol.

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Selenium-doped carbon dots inhibit ferroptosis by multi-hierarchy iron chelation and mitochondrial homeostasis regulation to control inflammation

Zhang,

Mao,

Zhao

et al. 2024

Chemical Engineering Journal

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Targeting ferroptosis offers therapy choice in sepsis-associated acute lung injury

Wang,

Zhang

et al. 2025

European Journal of Medicinal Chemistry

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Inhibition of CISD1 alleviates mitochondrial dysfunction and ferroptosis in mice with acute lung injury

Cited by 6 publications

References 29 publications

A critical appraisal of ferroptosis in Alzheimer’s and Parkinson’s disease: new insights into emerging mechanisms and therapeutic targets

A critical appraisal of ferroptosis in Alzheimer’s and Parkinson’s disease: new insights into emerging mechanisms and therapeutic targets

Selenium-doped carbon dots inhibit ferroptosis by multi-hierarchy iron chelation and mitochondrial homeostasis regulation to control inflammation

Targeting ferroptosis offers therapy choice in sepsis-associated acute lung injury

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