Inhibition of Clq Functions by RHP, a Protein Elevated in Sera from Patients with Rheumatoid Arthritis

Rosano, Carmen L.; Braun, Catherine B.; Hechemy, Karim E.; Parhami, N; Satoh, Paul S.; Hurwitz, Charles

doi:10.1159/000463036

Cited by 5 publications

(1 citation statement)

References 7 publications

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“…The inhibitor, described as a 60 kDa glycoprotein, exerts its effect by binding to immunoglobulin and inhibits complement activation through an effect on C1 binding. Yet another protein, designated RHP, with a molecular weight of 135 kDa, has also been isolated and purified from rheumatoid sera [22]. It is capable of inhibiting haemolytic activity initiated via the classical pathway, but at present it is not known whether this protein has inhibitory activity.…”

Section: Discussionmentioning

confidence: 99%

Complement-mediated inhibition of immune precipitation in rheumatoid vasculitis

et al. 1990

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Complement-mediated inhibition of immune precipitation (CMIP) was measured in patients with rheumatoid arthritis (RA), rheumatoid vasculitis (RA VASC), patients with skin vasculitis not associated with a systemic connective tissue disease and normal healthy controls. CMIP was impaired in 100% (14/14) of the RA vasculitic patients, 60% (12/20) of the RA patients and 22% (2/9) of the dermovasculitic patients. The degree of impairment of CMIP was significantly greater in the RA vasculitic patients compared to the non-vasculitic patients. This difference was due to the significantly lower complement levels and the presence of higher concentrations of an inhibitor of CMIP in the RA vasculitic sera. The levels of this inhibitory activity correlated significantly with IgM rheumatoid factor concentration. Serial studies in three patients with RA vasculitis treated with corticosteroids and immunosuppressive drugs showed significant clinical improvement in two patients, which was associated with improvement in CMIP, reduction in circulating immune complex levels and reduction in IgM rheumatoid factor concentrations.

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Section: Discussionmentioning

confidence: 99%

Complement-mediated inhibition of immune precipitation in rheumatoid vasculitis

et al. 1990

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Serum levels of RHP and of unbound C1q in rheumatoid arthritis and systemic lupus erythematosus

et al. 1988

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RHP is a recently described serum protein which inhibits a number of physiologic functions of C1q unbound to C1r2 x C1s2. In this report we show that sera from patients with rheumatoid arthritis contained elevated levels of RHP and of unbound C1q. Sera from patients with systemic lupus erythematosus contained normal levels of RHP and were characterized by deficits of C1q required to form C1 from existing levels of C1r and C1s.

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