Inhibition of colon C5a/C5a receptor signalling pathway confers protection against LPS-induced acute kidney injury via gut microbiota-kidney axis

Xie, Rong-Cheng; Zhang, Jin-Cheng; Lin, Xiao-Ming; Huang, Ting; Wang, Yu-Ting; Zhang, Lian-Fang; Hong, Xiang-Yu; Lin, Xue-Feng; Zheng, Hong-Jun; Luo, Zhe; Yi, Li-Tao; Ma, Jie-Fei

doi:10.1016/j.ejphar.2024.176425

Cited by 4 publications

(1 citation statement)

References 36 publications

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“…Previous studies have shown that AKI triggers inflammation and damages the intestinal barrier function, which is related to its disturbance of gut microbiota homeostasis. 43 Despite this, few studies have explored the relationship between nephrotoxic adenine-induced AKI and the gut microbiota. Our study identified significant changes in the gut microbiota composition of adenine-induced AKI mice and speculated the key role of different bacterial genera in AKI progression.…”

Section: Discussionmentioning

confidence: 99%

Bifidobacterium bifidum alleviates adenine-induced acute kidney injury in mice by improving intestinal barrier function

Meng,

Zhao,

et al. 2024

Food Funct.

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Section: Discussionmentioning

confidence: 99%

Bifidobacterium bifidum alleviates adenine-induced acute kidney injury in mice by improving intestinal barrier function

Meng,

Zhao,

et al. 2024

Food Funct.

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The complement system: A key player in the host response to infections

Jayaraman,

Walachowski,

Bosmann

2024

Eur J Immunol

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Infections are one of the most significant healthcare and economic burdens across the world as underscored by the recent coronavirus pandemic. Moreover, with the increasing incidence of antimicrobial resistance, there is an urgent need to better understand host–pathogen interactions to design effective treatment strategies. The complement system is a key arsenal of the host defense response to pathogens and bridges both innate and adaptive immunity. However, in the contest between pathogens and host defense mechanisms, the host is not always victorious. Pathogens have evolved several approaches, including co‐opting the host complement regulators to evade complement‐mediated killing. Furthermore, deficiencies in the complement proteins, both genetic and therapeutic, can lead to an inefficient complement‐mediated pathogen eradication, rendering the host more susceptible to certain infections. On the other hand, overwhelming infection can provoke fulminant complement activation with uncontrolled inflammation and potentially fatal tissue and organ damage. This review presents an overview of critical aspects of the complement‐pathogen interactions during infection and discusses perspectives on designing therapies to mitigate complement dysfunction and limit tissue injury.

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Toralactone alleviates cisplatin-induced acute kidney injury by modulating the gut microbiota-renal axis

Tian,

et al. 2024

International Immunopharmacology

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Inhibition of colon C5a/C5a receptor signalling pathway confers protection against LPS-induced acute kidney injury via gut microbiota-kidney axis

Cited by 4 publications

References 36 publications

Bifidobacterium bifidum alleviates adenine-induced acute kidney injury in mice by improving intestinal barrier function

Bifidobacterium bifidum alleviates adenine-induced acute kidney injury in mice by improving intestinal barrier function

The complement system: A key player in the host response to infections

Toralactone alleviates cisplatin-induced acute kidney injury by modulating the gut microbiota-renal axis

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