1970
DOI: 10.1161/01.res.26.6.743
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Inhibition of Coronary Vasodilating Action of Dipyridamole and Adenosine by Aminophylline in the Dog

Abstract: Experiments were performed to determine (1) whether intravenously administered aminophylline inhibits the coronary vasodilating effects of intravenous or intracoronary administration of dipyridamole or adenosine and (2) whether aminophylline locally administered in the coronary artery inhibits the vasodilating action of adenosine given intravenously or injected into the coronary artery. Coronary vasodilator responses to dipyridamole or adenosine were determined before and after administration of aminophylline.… Show more

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Cited by 151 publications
(35 citation statements)
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“…indonmethacin (5 X 10' M) has no effect on the calcium, sodium, or potassium fluxes of guinea pig heart muscle (26). The alpparent concentration of indomethacin in the heart-lung preparation in the present studies was either 2.8 X 10' M or 1.1 X 10' M but the effective concentration may have been considerably lower, since over 90% of indomethacin in canine plasma is protein bound (27 (5,29). Although it has not been proved, it has been speculated that the inhibition of the adenosine response is a result of the phosphodiesterase inhibition by the nmethylxanthines (30).…”
Section: Discussionmentioning
confidence: 50%
“…indonmethacin (5 X 10' M) has no effect on the calcium, sodium, or potassium fluxes of guinea pig heart muscle (26). The alpparent concentration of indomethacin in the heart-lung preparation in the present studies was either 2.8 X 10' M or 1.1 X 10' M but the effective concentration may have been considerably lower, since over 90% of indomethacin in canine plasma is protein bound (27 (5,29). Although it has not been proved, it has been speculated that the inhibition of the adenosine response is a result of the phosphodiesterase inhibition by the nmethylxanthines (30).…”
Section: Discussionmentioning
confidence: 50%
“…It Afonso, 1970;Sattin & Rall, 1970;Osswald, 1975;Ally & Nakatsu, 1976;Sawynok & Jhamandas, 1976;Okwuasaba et al, 1977). In contrast, dipyridamole and hexobendine have been shown to potentiate the inhibitory effect of adenosine and adenine nucleotide in the heart, intestine and trachea (Stafford, 1966;Kolassa, Pfleger & Rummel, 1970; At arrow, theophylline 30 gM was added to the superfusion solution.…”
Section: Discussionmentioning
confidence: 99%
“…Ainophylline was found to reduce by 50-75 % coronary vasodilator effects of adenosine administered i.v. or into the coronary artery (Afonso, 1970;Afonso & O'Brien, 1970). Although the intimate mechanism of this inhibitory action is not known, it has been suggested that aminophylline might act on the myocardium, or coronary vascular smooth muscle to produce this effect.…”
Section: Discussionmentioning
confidence: 99%