Inhibition of courtship and mating of Drosophila melanogaster by the male-produced lipid, cis-vaccenyl acetate

Zawistowski, S; Richmond, Rollin C.

doi:10.1016/0022-1910(86)90057-0

Cited by 93 publications

(69 citation statements)

References 12 publications

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“…D. simulans males, for example, do not court dead D. melanogaster males nearly as intensely as they court dead females of their own species, despite the fact that both courted genotypes have similar amounts of 7-T and other large hydrocarbons (5,14). This behavioral difference may be due to either the abdominal morphology of the dead males or pheromones not detected by our assay, such as the male-specific compound cis-vaccenyl acetate known to inhibit male courtship in D. melanogaster (35,36). Nevertheless, the mosaic studies show that female morphology cannot attract D. simulans males in the presence of a pheromonal difference, while a pheromonal similarity can partially overcome the effect of the morphological difference between the sexes.…”

Section: Discussionmentioning

confidence: 47%

Localization of pheromonal sexual dimorphism in Drosophila melanogaster and its effect on sexual isolation.

Coyne

Oyama

1995

Proc. Natl. Acad. Sci. U.S.A.

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Drosophila melanogaster is sexually dimorphic for cuticular hydrocarbons, with males and females having strikingly different profiles of the long-chain compounds that act as contact pheromones. Gas-chromatographic analysis of sexual mosaics reveals that the sex specificity of hydrocarbons is located in the abdomen. This explains previous observations that D. melanogaster males display the strongest courtship toward mosaics with female abdomens. We also show that males of the sibling species Drosophila simulans preferentially court D. melanogaster mosaics with male abdomens. Because the primary male hydrocarbon in D. melanogaster is also the primary female hydrocarbon in D. simulans, this supports the idea that interspecific differences in cuticular hydrocarbons contribute to sexual isolation.

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Section: Discussionmentioning

confidence: 47%

Localization of pheromonal sexual dimorphism in Drosophila melanogaster and its effect on sexual isolation.

Coyne

Oyama

1995

Proc. Natl. Acad. Sci. U.S.A.

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“…This quantity is four times that found on recently mated females (Lebreton et al, 2014) and 30-fold less than the dose of cVA that demonstrably activate Or67d receptor in absence of Lush (Gomez-Diaz et al, 2013). This dose has been previously shown to reduce male mating latency (Zawistowski and Richmond, 1986;Billeter et al, 2009). We tested two factors; the genotype of the males (wild-type or lush 1 ) and the presence or absence of cVA on virgin females (Figure 3).…”

Section: Lush Is Not Necessary For the Inhibitory Effect Of Cva On Mamentioning

confidence: 88%

The role of cVA and the Odorant binding protein Lush in social and sexual behavior in Drosophila melanogaster

Billeter¹,

Levine

2015

Front. Ecol. Evol.

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Social living is beneficial because it allows conspecifics to interact in ways that increase their chances of survival and reproduction. A key mechanism underlying these benefits is the ability to recognize conspecifics; thus, allowing the production of coordinated social interactions. Identification of such individuals is often through chemical communication: the individuals' pheromonal profile indicates their sex, species, and even past experiences. However, we know little about how the chemosensory system of conspecifics detects and how the nervous system processes this information. One of the best documented pheromonal detection mechanisms is that of cis-Vaccenyl Acetate (cVA) made by male Drosophila melanogaster and transferred to females during mating. Sensing of cVA by males inhibits courtship behavior toward already mated females. Sensing of cVA on other males also inhibits courtship and increases aggression. In this hybrid review/research article, we discuss the pheromonal system of Drosophila putting an emphasis on the molecular and cellular mechanisms involved in cVA sensing by the olfactory system, perception by the nervous system and ultimately the regulation of social interactions. The behavioral effect of cVA is context-as well as experience-dependent leading us to conclude that cVA plays a modulatory role in regulating social interactions rather than being a recognition pheromone. We also provide new behavioral data on the function of the Odorant Binding Protein Lush, which binds cVA in olfactory sensilla and help sensing this chemical. Our data indicate that lush may be involved in the sensing of additional pheromones to cVA and suggest the existence of a lush-independent cVA detection system. Interpretation of our data in the light of our current knowledge about pheromonal recognition in Drosophila indicates that this system is incompletely understood.

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“…Finally, the reduced courtship activity of Akhr null mutants, suggests that AKH could act at several levels to promote mating behavior. Previous studies showed that the DA1 glomerulus and its corresponding receptor Or67d mediate direct response to exposure to cVA (Schlief and Wilson, 2007;Wang and Anderson, 2010), whereas DL3 and the Or65a receptor seem to modulate cVA response over a longer period through experience (Zawistowski and Richmond, 1986;Everaerts et al, 2010;Liu et al, 2011;Lebreton et al, 2014;Dekker et al, 2015). AKHR is expressed in neurons with cell bodies in the SEZ.…”

Section: Discussionmentioning

confidence: 99%

“…Here we show that also AKH signaling appears important for flies in cVA attraction, since AKHR mutant males showed a significantly reduced attraction. cVA is transferred to females during mating and is used by males to recognize already mated females (Zawistowski and Richmond, 1986;Everaerts et al, 2010). Maintaining sensitive to cVA is therefore beneficial for males regarding both mate finding and sexual selection.…”

Section: Discussionmentioning

confidence: 99%

The Adipokinetic Hormone Receptor Modulates Sexual Behavior, Pheromone Perception and Pheromone Production in a Sex-Specific and Starvation-Dependent Manner in Drosophila melanogaster

et al. 2016

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Food availability and nutritional status shape the reproductive activity of many animals. In rodents, hormones such as gonadotropin-releasing hormone (GnRH), restore energy homeostasis not only through regulating e.g., caloric intake and energy housekeeping, but also through modulating sex drive. We investigated whether the insect homolog of the GnRH receptor, the adipokinetic hormone receptor (AKHR) modulates sexual behavior of the fruit fly Drosophila melanogaster depending on nutritional status. We found that AKHR regulates male, but not female sexual behavior in a starvation-dependent manner. Males lacking AKHR showed a severe decrease in their courtship activity when starved, as well as an increase in mating duration when fed. AKHR expression is particularly strong in the subesophageal zone (SEZ, Ito et al., 2014). We found axonal projections from AKHR-expressing neurons to higher brain centers including specific glomeruli in the antennal lobe. Among the glomeruli that received projections were those dedicated to detecting the male specific pheromone cis-vaccenyl acetate (cVA). Accordingly, responses to cVA were dependent on the nutritional status of flies. AKHR was also involved in the regulation of the production of cuticular pheromones, 7,11-heptacosadiene and 7-tricosene. This effect was observed only in females and depended on their feeding state. AKHR has therefore a dual role on both pheromone perception and production. For the first time our study shows an effect of AKHR on insect sexual behavior and physiology. Our results support the hypothesis of a conserved role of the GnRH/AKH pathway on a nutritional state-dependent regulation of reproduction in both vertebrates and invertebrates.

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Inhibition of courtship and mating of Drosophila melanogaster by the male-produced lipid, cis-vaccenyl acetate

Cited by 93 publications

References 12 publications

Localization of pheromonal sexual dimorphism in Drosophila melanogaster and its effect on sexual isolation.

Localization of pheromonal sexual dimorphism in Drosophila melanogaster and its effect on sexual isolation.

The role of cVA and the Odorant binding protein Lush in social and sexual behavior in Drosophila melanogaster

The Adipokinetic Hormone Receptor Modulates Sexual Behavior, Pheromone Perception and Pheromone Production in a Sex-Specific and Starvation-Dependent Manner in Drosophila melanogaster

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