Inhibition of crude viper venom action by silver nanoparticles: A biophysical and biochemical study

Chittaranjan, Hingane, Vrushali,; Pangam, Dhanashri S.; Dongre, Prabhakar M.

doi:10.2142/biophysico.15.0_204

Cited by 12 publications

(8 citation statements)

References 31 publications

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“…In this context, Gomes et al conjugated gold nps with the antivenomous compound 2-hydroxy-4-methoxy-benzoic acid (HMBA) extracted from the herb Anantamul ( H. indicus ), which was found to be effective in neutralizing all kinds of toxicity generated by the venom of the deadly Russell’s viper [ 118 ]. Likewise, silver nps were used to inhibit snake venom toxicity completely [ 119 ]. Recently, Chakrabartty et al found that TiO 2 nps are able to neutralize the venom-induced lethal activity of Daboia russelii and Naja kaouthia .…”

Section: Reviewmentioning

confidence: 99%

Engineered titania nanomaterials in advanced clinical applications

Sahare¹,

Alvarez²,

Yanez³

et al. 2022

Beilstein J. Nanotechnol.

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Significant advancement in the field of nanotechnology has raised the possibility of applying potent engineered biocompatible nanomaterials within biological systems for theranostic purposes. Titanium dioxide (titanium(IV) oxide/titania/TiO2) has garnered considerable attention as one of the most extensively studied metal oxides in clinical applications. Owing to the unique properties of titania, such as photocatalytic activity, excellent biocompatibility, corrosion resistance, and low toxicity, titania nanomaterials have revolutionized therapeutic approaches. Additionally, titania provides an exceptional choice for developing innovative medical devices and the integration of functional moieties that can modulate the biological responses. Thus, the current review aims to present a comprehensive and up-to-date overview of TiO2-based nanotherapeutics and the corresponding future challenges.

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Section: Reviewmentioning

confidence: 99%

Engineered titania nanomaterials in advanced clinical applications

Sahare¹,

Alvarez²,

Yanez³

et al. 2022

Beilstein J. Nanotechnol.

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“…2,3 This meets with the global strategy of the World Health Organization for the prevention and control of snakebite envenoming. 4,5 Considering that serum therapy is efficient for systemic but not for local effects and that it must be administered early after envenomation to increase the odds of a successful treatment, which is an unfavourable condition to inhabitants of rural areas from many countries, the nanoparticles come as a promising option against snakebites 6 and have already shown their value with the venoms of Naja nigricollis (Elapidae), 2 Doboia russellie (Viperidae), 7 Bothrops jararaca and Bothrops erythromelas (Viperidae), 8 Bothrops jararacussu (Viperidae), 9 Daboia russelii (Viperidae) and Naja kaouthia (Elapidae). 10,11 The reasons for use of the nanoparticles include the venom toxins bridging as the interface for drug delivery and targeted therapy, 6 as shown with the antigen delivery of encapsulated Naja naja oxiana venom in chitosan nanoparticles targeting tumor cells.…”

Section: Introductionmentioning

confidence: 99%

“…8 Nanoparticles have also been used for more specific objectives. The silver nanoparticles promote protection against the neuromuscular blockade induced by Bothrops jararacussu venom 9 and the proteolytic effects of Doboia russellie venom, 7 while abiotic hydrogel nanoparticle mitigates the progression of local tissue damage induced by a diverse array of phospholipases A 2 and 3FTX isoforms found in Naja nigricollis venom. 2 The Colubridae snakes Philodryas olfersii (P. olfersii) and Philodryas patagoniensis (popularly known as green snakes) are opisthoglyphous, considered as not poisonous, 13 and restricted to South America.…”

Section: Introductionmentioning

confidence: 99%

“…Considering that serum therapy is efficient for systemic but not for local effects and that it must be administered early after envenomation to increase the odds of a successful treatment, which is an unfavourable condition to inhabitants of rural areas from many countries, the nanoparticles come as a promising option against snakebites 6 and have already shown their value with the venoms of Naja nigricollis (Elapidae), 2 Doboia russellie (Viperidae), 7 Bothrops jararaca and Bothrops erythromelas (Viperidae), 8 Bothrops jararacussu (Viperidae), 9 Daboia russelii (Viperidae) and Naja kaouthia (Elapidae). 10 , 11 …”

Section: Introductionmentioning

confidence: 99%

“…Nanoparticles have also been used for more specific objectives. The silver nanoparticles promote protection against the neuromuscular blockade induced by Bothrops jararacussu venom 9 and the proteolytic effects of Doboia russellie venom, 7 while abiotic hydrogel nanoparticle mitigates the progression of local tissue damage induced by a diverse array of phospholipases A 2 and 3FTX isoforms found in Naja nigricollis venom. 2 …”

Section: Introductionmentioning

confidence: 99%

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The Influence of Silver Nanoparticles Against Toxic Effects of Philodryas olfersii Venom

Proença-Assunção

Farias-de-França

Tribuiani

et al. 2021

IJN

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Purpose: A silver nanoparticle obtained by reducing salts with solid dispersion of curcumin (130 nm, 0.081 mg mL −1 ) was used to counteract against the toxic -edematogenic, myotoxic, and neurotoxic -effects of Philodryas olfersii venom. Methods: The edematogenic effect was evaluated by plasma extravasation in rat dorsal skin after injection of 50 µg per site of venom alone or preincubated with 1, 10, and 100 µL of AgNPs; the myotoxicity was evaluated by measuring the creatine kinase released into the organ-bath before the treatment and at the end of each experiment; and neurotoxicity was evaluated in chick biventer cervicis using the conventional myographic technique, face to the exogenous acetylcholine (ACh) and potassium chloride (KCl) added into the bath before the treatment and after each experiment. Preliminarily, a concentration-response curve of AgNPs was carried out to select the concentration to be used for neutralizing assays, which consists of neutralizing the venom-induced neuromuscular paralysis and edema by preincubating AgNPs with venom for 30 min. Results: The P. olfersii venom-induced edema (n=6) and a complete neuromuscular blockade (n=4) that includes the total and unrecovered block of ACh and KCl contractures. AgNPs produced a concentration-dependent decrease the venom-induced edema (n=6) from 223.3% to 134.4% and to 100.5% after 10 and 100 µL AgNPs-preincubation, respectively. The preincubation of venom with AgNPs (1 µL; n=6) was able to maintain 46.5 ± 10.9% of neuromuscular response under indirect stimuli, 39.2 ± 9.7% of extrinsic nicotinic receptors functioning in absence of electrical stimulus and 28.3 ± 8.1% of responsiveness to potassium on the sarcolemmal membrane. The CK release was not affected by any experimental protocol which was like control. Conclusion: AgNPs interact with constituents of P. olfersii venom responsible for the edema-forming activity and neuromuscular blockade, but not on the sarcolemma membraneacting constituents. The protective effect of the studied AgNPs on avian preparation points out to molecular targets as intrinsic and extrinsic nicotinic receptors.

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