2017
DOI: 10.3390/medicines4040080
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Inhibition of Cyclic Adenosine Monophosphate-Specific Phosphodiesterase by Various Food Plant-Derived Phytotherapeutic Agents

Abstract: Background: Phosphodiesterases (PDEs) play a major role in the regulation of cyclic adenosine monophosphate (cAMP)- and cyclic guanosine monophosphate (cGMP)-mediated pathways. Their inhibitors exhibit anti-inflammatory, vasodilatory and antithrombotic effects. Therefore, consumption of foods with PDE-inhibiting potential may possess beneficial influence on the risk of cardiovascular diseases. Methods: Four plant extracts (Arbutus unedo, Camellia sinensis, Cynara scolymus, Zingiber officinale) with promising i… Show more

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Cited by 18 publications
(12 citation statements)
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“…In addition, Röhrig and coworkers tested the following polyphenol-rich extracts on PDE isolated from the lung tumor xenograft cell line LXFL529L: artichoke (Cynara scolymus) extract, which had a significant inhibitory influence on PDE activity (IC 50 = 0.9 ± 0.1 mg/mL); the flavones luteolin (IC 50 = 41 ± 10 µM) and 3,4-dicaffeoylquinic acid (IC 50 > 1.0 mM), and strawberry tree fruit (Arbutus unedo) extract, which showed no inhibitory effect on PDE at levels below 5 mg/mL. A plausible explanation for the lack of inhibition by the strawberry tree extract could be low AC content [25], as strawberry tree fruit has an AC content of only 0.51 mg per 100 g of fresh fruit [30].…”
Section: Discussionmentioning
confidence: 99%
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“…In addition, Röhrig and coworkers tested the following polyphenol-rich extracts on PDE isolated from the lung tumor xenograft cell line LXFL529L: artichoke (Cynara scolymus) extract, which had a significant inhibitory influence on PDE activity (IC 50 = 0.9 ± 0.1 mg/mL); the flavones luteolin (IC 50 = 41 ± 10 µM) and 3,4-dicaffeoylquinic acid (IC 50 > 1.0 mM), and strawberry tree fruit (Arbutus unedo) extract, which showed no inhibitory effect on PDE at levels below 5 mg/mL. A plausible explanation for the lack of inhibition by the strawberry tree extract could be low AC content [25], as strawberry tree fruit has an AC content of only 0.51 mg per 100 g of fresh fruit [30].…”
Section: Discussionmentioning
confidence: 99%
“…The inhibitory effect of each extract on PDE 3B was measured according to the method published by Pöch et al [ 34 ] with slight modifications [ 25 , 32 ]. One hundred microliters (100 µL) of the sample and 20 µL of PDE 3B (200 Units/mL) were incubated for 15 min at 4°C.…”
Section: Methodsmentioning
confidence: 99%
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“…It should be pointed out that caffeine also functions as a PDE inhibitor (Rohrig et al, 2017), which increases cAMP concentration and PKA activation at cellular level. Therefore, we cannot completely exclude the possibility that caffeine-induced enhancement of SOCE may be partially attributed to SR Ca 2+ load-independent pathway, e.g., PKA-dependent activation.…”
Section: Discussionmentioning
confidence: 99%