1972
DOI: 10.1016/0006-291x(72)90700-0
|View full text |Cite
|
Sign up to set email alerts
|

Inhibition of DNA repair by cocarcinogens

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1

Citation Types

0
10
0

Year Published

1974
1974
2003
2003

Publication Types

Select...
4
3
1

Relationship

0
8

Authors

Journals

citations
Cited by 52 publications
(10 citation statements)
references
References 10 publications
0
10
0
Order By: Relevance
“…Earlier work from this laboratory indicates that this same mechanism can also explain the mechanism of cocarcinogenesis by some steroids as well as by numerous other cocarcinogens ( 1,2 ) .…”
mentioning
confidence: 80%
See 2 more Smart Citations
“…Earlier work from this laboratory indicates that this same mechanism can also explain the mechanism of cocarcinogenesis by some steroids as well as by numerous other cocarcinogens ( 1,2 ) .…”
mentioning
confidence: 80%
“…40 1 toward the alkylating agents and X-rays. Additional support for this concept has been provided by earlier work from this laboratory in which it was demonstrated that inhibitors of the repair process can sensitize experimental animal tumors toward these agents (3,4,9). Tumors used in these experiments included both cyclophosphamide-resistant and cyclophosphamide-sensitive plasmacytomas and melanomas implanted in hamsters.…”
mentioning
confidence: 86%
See 1 more Smart Citation
“…Under in vitro conditions, dithranol al ters the physical and spectral properties of dissolved DNA, which is suggestive of a chemical interaction between DNA and dithranol [57], However, this direct interac tion was disproved later [58], Although the inhibitory effect of dithranol on DNA syn thesis and repair function was confirmed in vitro in various cell lines [59][60][61][62][63], recent results suggest that this is not a specific effect on the DNA, but rather a more general effect on cell metabolism [44][45][46]58].…”
Section: Inhibition O F Dna Replication and Repairmentioning
confidence: 99%
“…The mutagenicity of many metals was tested by Nishioka using E. coli (4). Toxic posed for tumor promoters (6). Cocarcinogens, according to this model, might turn normal cells into phenocopies of Xeroderma pigmentosum cells, which carry a genetic defect for DNA repair leading to multiple skin cancers (7).…”
Section: Introductionmentioning
confidence: 99%