Inhibition of dorsal column by nuclei stimulation of trigeminal afferents in decerebrate—decerebellate cats

Saadé, Nayef E.; Dajani, Badr M.; Atweh, Samir; Jabbur, Suhayl J.

doi:10.1016/0006-8993(85)90467-6

Cited by 6 publications

(1 citation statement)

References 11 publications

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“…low frequency electrical stimulation of Aδ fibers may cause a durable depression of nociceptive C fiber transmission both in vivo (Sjölund 1985;Sjölund 1988) and in vitro spinal preparations (Sandkühler et al 1997) and noxious mechanical stimulation, such as scratching, reduces itch. These interactions occur at several levels in the somatosensory system, the dorsal horn of the spinal cord (Cervero et al 1979;, the dorsal column nuclei (Saade et al 1985) and the thalamus (Olausson et al 1994) and are often topographically well organized. To use these interactions for the symptomatic relief of itch and pain, a new technique, termed cutaneous field stimulation (CFS), was introduced (Nilsson et al 1997).…”

Section: Characteristicsmentioning

confidence: 99%

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Encyclopedia of Pain

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Calcium channels that open upon depolarization (voltage-dependent calcium channels, VDCCs) enable calcium ions to enter neurons. VDCCs are thereby involved in synaptic transmission, changes in membrane excitability, intracellular regulation of second and third messengers and expression of genes. Spinal VDCCs that are opened by relatively large depolarizations (highthreshold VDCCs) or by small depolarizations (lowthreshold VDCCs) are involved in normal nociception as well as in the hyperalgesia and allodynia that result from inflammatory and mechanical lesions of peripheral tissues or from lesions of primary afferents fibers. Characteristics Voltage-Dependent Calcium Channels References 1. Atanassoff PG, Hartmannsgruber MW, Thrasher J et al. (2000) Ziconotide, a new N-type calcium channel blocker, administered intrathecally for acute postoperative pain. Reg Anesth Pain Med 25:274-278 2. Brose WG, Gutlove DP, Luther RR et al. (1997) Use of intrathecal SNX-111, a novel, N-type, voltage-sensitive, calcium channel blocker, in the management of intractable brachial plexus avulsion pain.

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