Inhibition of DXR in the MEP pathway with lipophilic <i>N</i>-alkoxyaryl FR900098 analogs

Bague, Darean; Wang, Ruiqin; Hodge, Dana; Mikati, Marwa O.; Roma, Jose S.; Boshoff, Helena I.; Dailey, Allyson L.; Girma, Misgina; Couch, Robin D.; Odom John, Audrey R.; Dowd, Cynthia S.

doi:10.1039/d3md00642e

RSC Med. Chem.

2024

DOI: 10.1039/d3md00642e

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Inhibition of DXR in the MEP pathway with lipophilic N-alkoxyaryl FR900098 analogs

Darean Bague,

Ruiqin Wang,

Dana Hodge

et al.

Abstract: In Mycobacterium tuberculosis (Mtb) and Plasmodium falciparum (Pf), the methylerythritol phosphate (MEP) pathway is responsible for isoprene synthesis. This pathway and its products are vital to bacterial/parasitic metabolism and survival,...

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Inhibition of DXR in the MEP pathway with lipophilic N-alkoxyaryl FR900098 analogs

Abstract: In Mycobacterium tuberculosis (Mtb) and Plasmodium falciparum (Pf), the methylerythritol phosphate (MEP) pathway is responsible for isoprene synthesis. This pathway and its products are vital to bacterial/parasitic metabolism and survival,...

Cited by 0 publications

References 54 publications

No citations

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