Inhibition of Endostatin/Collagen XVIII Deteriorates Left Ventricular Remodeling and Heart Failure in Rat Myocardial Infarction Model

Abstract

Neutralization of endostatin worsens the symptoms and outcomes of MI in a rat model. The results imply that endogenous endostatin/collagen XVIII may suppress aberrant LV remodeling and heart failure after MI. (Circ J 2010; 74: 109 - 119).

Is Structural Remodeling of Fibrillated Atria the Consequence of Tissue Hypoxia?

“…13,14,17- 21 We previously demonstrated that MMP-9 expression increases in fibrillating atrial tissue, which may contribute to the atrial structural remodeling of AF. 22 However, the mechanism of the increase in MMP-9 expression in fibrillating atrial tissue remains unknown.…”

Endostatin stimulates proliferation and migration of adult rat cardiac fibroblasts through PI3K/Akt pathway

“…Serum endostatin level in the coronary circulation was upregulated in coronary heart disease (Mitsuma et al, 2007). Expression of endostatin increases in the heart tissues of experimental cardiac disease models, such as myocardial infarction (Isobe et al, 2010;Qipshidze et al, 2012) and pressure overload-induced cardiac hypertrophy (Givvimani et al, 2011;Nikolova et al, 2012). In addition, antiendostatin antibody worsened cardiac remodeling after myocardial infarction (Isobe et al, 2010).…”

Predictive Value of Endostatin in Chronic Heart Failure Patients with Poor Kidney Function

“…The extracellular matrix plays an important role in left ventricular (LV) remodeling, and changes in expression patterns of extracellular matrix proteins may contribute to HF progression. Experimental data demonstrate abundant expression of the anti-angiogenic factor endostatin in cardiac tissue, suggesting a potential role in myocardial remodeling during HF [1]. Furthermore, Gouya et al [2] recently demonstrated that high serum endostatin levels were associated with all-cause mortality in a relatively small study population of HF patients.…”