2004
DOI: 10.1167/iovs.03-0492
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Inhibition of Endotoxin-Induced Uveitis and Potentiation of Cyclooxygenase-2 Protein Expression by α-Melanocyte–Stimulating Hormone

Abstract: This study suggests that alpha-MSH has an antiocular inflammatory effect, by suppression of PGE2, TNF-alpha, IL-6, and MCP-1 production and blocking of COX-2 expression.

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Cited by 45 publications
(31 citation statements)
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“…EIU is used as an animal model of acute anterior ocular inflammation in humans [1][2][3][4][5][6][7][8][9][10][11][12]. Systemic injection of LPS caused inflammation of the anterior chamber of the eye, characterized by increased neutrophil infiltration and cytokine levels in the AH [2].…”
Section: Discussionmentioning
confidence: 99%
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“…EIU is used as an animal model of acute anterior ocular inflammation in humans [1][2][3][4][5][6][7][8][9][10][11][12]. Systemic injection of LPS caused inflammation of the anterior chamber of the eye, characterized by increased neutrophil infiltration and cytokine levels in the AH [2].…”
Section: Discussionmentioning
confidence: 99%
“…Systemic injection of LPS caused inflammation of the anterior chamber of the eye, characterized by increased neutrophil infiltration and cytokine levels in the AH [2]. The inflammatory and immune response involves a transcriptional regulatory factor, NF-kB, which regulates the expression of a number of cytokines [4][5][6][7][8][9][10][11][12].…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Therapeutic α-MSH-treatments have been tried in animal models of septic shock, contact dermatitis, rheumatoid arthritis, acute pancreatitis, toxin-induced liver failure, allergic airway inflammation, endotoxin induce uveitis, and experimental autoimmune uveoretinitis (Ceriani et al, 1994;Grabbe et al, 1996;Jahovic et al, 2004;Martin and Lipton, 1990;Nishida et al, 2004;Raap et al, 2003;Shiratori et al, 2004;Taylor et al, 2000;Wang et al, 2004). In addition, two other groups of researchers have attempted to use different forms of gene therapy to see if delivering α-MSH into the immune response of EAE will suppress the onset and subsequent pathology of EAE.…”
Section: Discussionmentioning
confidence: 99%
“…In addition, our research into the immunosuppressive activity of α-MSH and its importance in ocular immune privilege has demonstrated the dynamic contribution of the nervous system to immunoregulation. Further understanding of α-MSH immunomodulating activity will continue to promote the use α-MSH in a therapeutic manner to subdue inflammation and to manipulate immunity to prevent induction of inflammation resulting from specific infections and autoimmune diseases (Casalino-Matsuda et al, 2002;Colombo et al, 2002;Huang et al, 1998;Namba et al, 2002;Nishida et al, 2004;Shiratori et al, 2004). The effects of α-MSH on nitric oxide production by macrophages stimulated by specific TLR.…”
Section: Discussionmentioning
confidence: 99%