Inhibition of exploratory behavior in the rat by handling

Lorenzini, Carlo Ambrogi; Bucherelli, Corrado; Giachetti, A; Tassoni, Giovanna

doi:10.3758/bf03205258

Cited by 9 publications

(2 citation statements)

References 24 publications

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“…Because it is likely that locomotion more fully reflects exploratory activity than does wall climbing, it may be the case that, in the latter studies, novelty-induced exploration on the first session was sufficiently intense to yield scores as high as those of the conditioned response (which, as suggested by our results, probably did not arise from a failure to habituate to novelty). Moreover, handling during treatment, which may have attenuated certain components of exploratory activity in rats and mice (e.g., Lorenzini, Bucherelli, Giachetti, & Tassoni, 1990; Terry, 1992), may also have reduced the difference between the spontaneous locomotion and conditioned response. Note that this aspect was controlled in the present study, in which only similarly handled subjects were compared.…”

Section: Discussionmentioning

confidence: 99%

Conditioning of and contextual sensitization to apomorphine-induced climbing in mice: Evidence against the habituation hypothesis.

Tirelli¹,

Heidbreder²

1999

Behavioral Neuroscience

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Several predictions of the habituation hypothesis of conditioned drug effects were tested by looking at contextual sensitization to apomorphine-induced climbing in mice (Mus musculus). Mice were first sensitized to that effect after 9 daily injections of 0.4 mg/kg apomorphine in the test context. Other mice received the same treatment outside the test context. On Day 10, all mice were challenged with either saline (conditioned drug effects test) or apomorphine (contextual sensitization test). On both tests, the levels of climbing of mice that received apomorphine paired with the test context during the intermittent treatment were significantly higher than those of mice that were experiencing the test context for the first time (unexposed mice). Also, the rate of extinction in conditioned mice did not parallel the rate of habituation in the unexposed mice. Results contradict the habituation hypothesis of conditioned drug effects and contextual sensitization.

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Section: Discussionmentioning

confidence: 99%

Conditioning of and contextual sensitization to apomorphine-induced climbing in mice: Evidence against the habituation hypothesis.

Tirelli¹,

Heidbreder²

1999

Behavioral Neuroscience

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“…This could be considered in assays assessing anxiety-like behaviors or social interactions but also in any assay assessing exploratory activity. In addition to general handling, the time of handling prior to or within a test can present as a variable ( Lorenzini et al, 1990 ; Schmitt and Hiemke, 1998 ; Gouveia and Hurst, 2017 ).…”

Section: Sources Of Variabilitymentioning

confidence: 99%

Roadbumps at the Crossroads of Integrating Behavioral and In Vitro Approaches for Neurotoxicity Assessment

Harry¹,

McBride²,

Witchey³

et al. 2022

Front. Toxicol.

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With the appreciation that behavior represents the integration and complexity of the nervous system, neurobehavioral phenotyping and assessment has seen a renaissance over the last couple of decades, resulting in a robust database on rodent performance within various testing paradigms, possible associations with human disorders, and therapeutic interventions. The interchange of data across behavior and other test modalities and multiple model systems has advanced our understanding of fundamental biology and mechanisms associated with normal functions and alterations in the nervous system. While there is a demonstrated value and power of neurobehavioral assessments for examining alterations due to genetic manipulations, maternal factors, early development environment, the applied use of behavior to assess environmental neurotoxicity continues to come under question as to whether behavior represents a sensitive endpoint for assessment. Why is rodent behavior a sensitive tool to the neuroscientist and yet, not when used in pre-clinical or chemical neurotoxicity studies? Applying new paradigms and evidence on the biological basis of behavior to neurobehavioral testing requires expertise and refinement of how such experiments are conducted to minimize variability and maximize information. This review presents relevant issues of methods used to conduct such test, sources of variability, experimental design, data analysis, interpretation, and reporting. It presents beneficial and critical limitations as they translate to the in vivo environment and considers the need to integrate across disciplines for the best value. It proposes that a refinement of behavioral assessments and understanding of subtle pronounced differences will facilitate the integration of data obtained across multiple approaches and to address issues of translation.

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Restraint increases both aggression and defence in female rats tested against same-sex unfamiliar conspecifics

Albonetti

Farabollini

1993

Aggr. Behav.

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Female rate living in groups were subjeccted to single and repeated immobllization stress (Restraint, RT). Twenty‐four hours after RT, or the last RT session in the case of repeated RT, social behavior was recored in encounters with unfamilar females, matched for age and body weight. Single RT caused an increase in agonistic behavior in both its aggression and defence aspects. This was a specific effect, as other behaviors, including introductory, affiliative (Allo‐Grooming), and courting items, were unifluenced by Rate The effect persisted and was even strengthened in the case of aggression, when RT was repeated once a day for 7 consecutive days. These findings, together with previous data showing a reduction in emotionality and an increase in the exploration of the physical environment following RT, suggest that in females mild stress may induce behavioral arousal, with the selective activation of specific social and non‐social behavioral parameters. This contrasts with previous findings in male rats, which responded to RT with the depression of several behavioral parameters, including some of the items (aggresion, exploration) activated in females. As already found in males, in females some parameters were affected by repetition of treatment, either RT or control handing. This suggests that manipulation per se does affect social behavior. However, behavioral modifications ascribable to repeated manipulation in no way superimposed, and were clearly distinguish able from, those due to RT. © 1993 Wiley‐Liss, Inc.

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Inhibition of exploratory behavior in the rat by handling

Cited by 9 publications

References 24 publications

Conditioning of and contextual sensitization to apomorphine-induced climbing in mice: Evidence against the habituation hypothesis.

Conditioning of and contextual sensitization to apomorphine-induced climbing in mice: Evidence against the habituation hypothesis.

Roadbumps at the Crossroads of Integrating Behavioral and In Vitro Approaches for Neurotoxicity Assessment

Restraint increases both aggression and defence in female rats tested against same-sex unfamiliar conspecifics

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