Inhibition of formylmethionyl-leucyl-phenylalanine-stimulated neutrophil chemiluminescence by human immunoglobulin A paraproteins

Epps, Dennis E. Van; Brown, Simon

doi:10.1128/iai.34.3.864-870.1981

Cited by 33 publications

(13 citation statements)

References 13 publications

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“…More recently, we also identified it as the receptor mediating the long‐recognized inhibitory responses induced by monomeric IgA, the second most predominant Ig in the serum (7, 8). Indeed, monomeric IgA can inhibit myeloid cell responses, leading to a plethora of functional consequences, including a powerful blockade of phagocytosis, oxidative burst, and cytokine production (7, 36–41). FcαRI can bind IgA1 and IgA2 with low affinity ( K a ∼ 10 6 /M) in the boundaries of CHα2 and CHα3 domains (35).…”

Section: The Emergence Of Itami As An Inhibitory Mechanismmentioning

confidence: 99%

Inhibitory ITAMs as novel regulators of immunity

Blank

Launay

Benhamou

et al. 2009

Immunological Reviews

151

142

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Immune homeostasis is regulated by a finely tuned network of positive-negative regulatory mechanisms that guarantees proper surveillance avoiding hyperactivity that would lead to autoimmunity and inflammatory diseases. Immune responses involve the activation of immunoreceptors that contain tyrosine-based activation motifs (ITAMs). One arm of control involves immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing receptors, which upon co-aggregation initiate an inhibitory signal through recruitment of signal-aborting phosphatases. Recently, a new immunoregulatory function has been ascribed to ITAMs, which represent in fact dual function modules that, under specific configurations termed inhibitory ITAM (ITAMi), can propagate inhibitory signals. One paradigm is the immunoglobulin A (IgA) Fc receptor (FcalphaRI), which, upon interaction with IgA monomers in the absence of antigen, initiates a powerful inhibitory signal involving Src homology 2 domain-containing phosphatase 1 (SHP-1) recruitment that suppresses cell activation launched by a whole variety of heterologous receptors without co-aggregation. This explains the long known function of IgA as an anti-inflammatory isotype. The importance of this control mechanism in immune homeostasis is underlined by the high incidence of autoimmune and allergic diseases in IgA-deficient patients. ITAMi is now described for an increasing number of immunoreceptors with multiple roles in immunity. ITAMi signaling is also exploited by Escherichia coli to achieve immune evasion during sepsis. Here, we review our current understanding of ITAMi regulatory mechanisms in immune responses and discuss its role in immune homeostasis.

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Section: The Emergence Of Itami As An Inhibitory Mechanismmentioning

confidence: 99%

Inhibitory ITAMs as novel regulators of immunity

Blank

Launay

Benhamou

et al. 2009

Immunological Reviews

151

142

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“…A regulatory effect of IgA on phagocytic cells such as monocytes and neutrophils is brought about by the interaction of IgA with the FcR (CD89) capable of binding monomeric IgA, secretory IgA and IgA immune complexes [5,6]. Interaction of IgA with FcR has been reported to down-modulate directed locomotion [7][8][9][10], phagocytosis [11,12] and the generation of reactive oxygen radicals [13,14] in phagocytes. The aim of our investigation was the further clarification of the anti-inflammatory potential of IgA.…”

Section: Introductionmentioning

confidence: 99%

Anti-inflammatory properties of human serum IgA: induction of IL-1 receptor antagonist and FcαR (CD89)-mediated down-regulation of tumour necrosis factor-alpha (TNF-α) and IL-6 in human monocytes

Wolf

Hauber

Gulle

et al. 1996

Clinical and Experimental Immunology

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SUMMARYA deregulated expression and/or release of large amounts of inflammatory cytokines such as IL-1 and TNF-® accounts for most pathophysiological events in a variety of systemic inflammatory diseases, the effect being mediated by the interaction of these cytokines with their respective receptors. IL-1 receptor antagonist (IL-1Ra), mainly produced by monocytes/macrophages, is an inhibitor of IL-1 activity. The present study shows that human serum IgA induces significant IL-1Ra release in human peripheral blood mononuclear cells and adherent monocytes. IgA induced higher levels of IL-1Ra than Haemophilus influenzae type b (Hib) expressing lipopolysaccharide (LPS), purified LPS or phorbol myristate acetate (PMA), without induction of IL-1¯release, and even inhibited LPS-induced IL-1r elease. Induction of IL-1Ra by IgA could be detected both at the mRNA and protein levels in resting and activated monocytes. Ligation of Fc®R with MoAb MY-43 or treatment with human serum IgA induced protein tyrosine phosphorylation in human monocytes, and herbimycin A, a specific inhibitor of protein tyrosine kinase activity, inhibited IgA-induced IL-1Ra production, suggesting that Fc®R-mediated induction of tyrosine phosphorylation is required for the IgA-induced stimulation of IL-1Ra release. In addition, triggering of Fc®R with MoAb specifically down-regulated TNF-® and IL-6 release in human monocytes activated with Hib. By the induction of IL-1Ra and down-regulation of the release of inflammatory cytokines such as IL-1¯, TNF-® and IL-6, interaction of IgA with human monocytes may actively contribute to the regulation of the inflammatory response.

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“…66 Recently, it was described that the pentraxin C-reactive protein (CRP) can bind to FcαRI, which been described for some time, but the mechanisms were poorly understood. [91][92][93][94][95][96][97] Pasquier, et al unravelled the underlying molecular mechanism by showing that SHP-1 is recruited to FcαRIassociated FcRγ chain, which blocks activating signals via Syk, induced by other Fc receptors. 89 This inhibitory capacity through FcRγ chain ITAM is referred to as ITAMi.…”

Section: Iga Receptorsmentioning

confidence: 99%

Immunoglobulin A

Bakema

Egmond

2011

mAbs

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Although immunoglobulin (Ig) A is commonly recognized as the most prevalent antibody subclass at mucosal sites with an important role in mucosal defense, its potential as a therapeutic monoclonal antibody is less well known. However, IgA has multifaceted anti-, non-, and pro-inflammatory functions that can be exploited for different immunotherapeutical strategies, which will be the focus of this review.

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Inhibition of formylmethionyl-leucyl-phenylalanine-stimulated neutrophil chemiluminescence by human immunoglobulin A paraproteins

Cited by 33 publications

References 13 publications

Inhibitory ITAMs as novel regulators of immunity

Inhibitory ITAMs as novel regulators of immunity

Anti-inflammatory properties of human serum IgA: induction of IL-1 receptor antagonist and FcαR (CD89)-mediated down-regulation of tumour necrosis factor-alpha (TNF-α) and IL-6 in human monocytes

Immunoglobulin A

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