Inhibition of gastric acid secretion in the rat by high calcium

Fisher, Hans; Kaufman, Raymond H.; Hsu, Hui‐Chen; Kasziba, Eva; Farmanfarmaian, A.; Flancbaum, Louis

doi:10.1016/s0271-5317(05)80136-8

Cited by 9 publications

(8 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Alfalfa hay contains calcium between 15 -26.3 g/kg dry matter (Cuddeford 1994). A high intake of calcium reduced the basal HCl secretion in rats (Fisher et al 1990). This effect was supposed to be a result of higher extra-and intracellular calcium concentrations in parietal and G-cells.…”

Section: Discussionmentioning

confidence: 99%

“…This effect was supposed to be a result of higher extra-and intracellular calcium concentrations in parietal and G-cells. Higher extra-and intracellular calcium concentrations may lower the cAMP concentration, thus reduEffects of alfalfa chaff on the gastric mucosa in adult horses S. Vondran et al cing the production of HCl (Fisher et al 1990). Exposure of the equine gastric mucosa to HCl and short chain fatty acids (SCFAs) decreased sodium transport of the cells significantly.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Effects of alfalfa chaff on the gastric mucosa in adult horses

Vondran¹,

Venner²,

Coenen³

et al. 2017

PHK

View full text Add to dashboard Cite

Summary: Feeding alfalfa hay is often recommended because of its buffering properties associated with substances, like protein and calcium, to prevent lesions. However, the particle size of the alfalfa preparations seems to have an influence on gastric mucosa in weanlings. We hypothesized that feeding alfalfa chaff with harsh particles would negatively impact glandular gastric mucosa in adult horses under maintenance conditions. The study was performed as a cross-over 2 × 2 Latin square design with 16-days washout intervals over 8 weeks. Six geldings (19 to 21 years of age) were kept in individual boxes (10.85 m 2 ). The horses were fed 1.5 kg per 100 kg BW of alfalfa chaff or grass hay, offered twice a day. Horses were subjected to a gastroscopy immediately before the feeding period (T= 0), after the first feeding period of 12 days (T =12), after the first washout period (T = 28), after the second feeding period of 12 days (T = 40) and after the second washout period (T = 56). When horses were fed alfalfa chaff the median score of the antrum raised from 0 to 2 (p = 0.07). And after the washout period the median score of the antrum decreased to 0.5 (p = 0.04). In conclusion feeding alfalfa chaff induced glandular mucosal lesions at the antrum. Lesions of the antrum induced by feeding alfalfa chaff seem to be reversible and to heal within 16 days. Keywords: alfalfa, particle size, gastric lesions, gastroscopy, EGGD, nutrition Citation: Vondran S., Venner M. , Coenen M., Vervuert I. (2017) Effects of alfalfa chaff on the gastric mucosa in adult horses. Pferdeheilkunde 33, 66-71;

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Effects of alfalfa chaff on the gastric mucosa in adult horses

Vondran¹,

Venner²,

Coenen³

et al. 2017

PHK

View full text Add to dashboard Cite

show abstract

“…Alfalfa is rich in protein and calcium and is, therefore, often recommended for its buffering properties, to prevent gastric lesions (Vondran et al 2017). In rats, the basal secretion of gastric acid was inhibited when a high-calcium diet was fed (Fisher et al 1990). The same effect was seen in horses fed an alfalfa hay-grain diet (Nadeau et al 2000).…”

Section: Discussionmentioning

confidence: 99%

The impact of feeding a high-fibre and high-fat concentrated diet on the recovery of horses suffering from gastric ulcers

Böhm¹,

Mitterer²,

Iben³

2018

PHK

View full text Add to dashboard Cite

The objective of this study was to find out whether a change from a grain-rich concentrated feed to a grain-free, fibre-and fatenriched concentrated diet (FFD), leads to an improvement in gastric ulcers in horses. The experiment was conducted as a prospective experimental study. Thirty-four adult horses with gastric lesions-six mares and 28 geldings-fulfilled the inclusion criteria of this study. The average age was 11± 4 (mean ± SD) years and the horses weighed between 358 kg and 697 kg. Twenty horses were fed the FFD, while 14 horses were controls (C) and received their usual concentrated feed. Each horse underwent gastroscopy twice, at an interval of eight weeks. An independent evaluation of the examination and the scoring of the lesions, using the Equine Gastric Ulcer Council 0-4 scoring system for equine gastric ulcer syndrome (EGUS), was performed by an experienced gastroscopist. The horses with EGUS scores ≥ 3 received additional omeprazole at the recommended dosage for 14 days. The horses of the FFD group were adapted to the new diet whereas the control group received their usual concentrate. In the control group, only the amounts of hay and concentrate were adjusted to the requirement of the respective horse. After the change of the ration, the starch intake (FFD 0.09 ± 0.05 g/kg BW; C 1.38 ± 0.62 g/kg BW) was significantly different. However, there was no difference concerning the hay intake (FFD 21.2 ± 3.5 g/kg BW/day; C 23.3 ± 5.1 g/kg BW/day), the Ca intake (FFD 0.129± 0.034 g/kg BW/day; C 0.112 ± 0.019 g/kg BW/day), the Mg intake (FFD 0.042 ± 0.009 g/kg BW/day; C 0.042 ± 0.011g/kg BW/day) or the intake of the praecaecal digestible protein (FFD 1.42 ± 0.38 g/kg BW/day; C 1.58 ± 0.39 g/kg BW/day). The prevalence and severity of the mucosal lesions significantly decreased in the FFD group (p<0.001). No significant correlation between the EGUS and the other risk factors, such as workload, behaviour or typical symptoms was found in this study. The change of the concentrated feed to FFD improved the gastric ulcerations in both squamous and glandular mucosa.

show abstract

“…In that context nutrients such as calcium, magnesium and protein may contribute to an increase in gastric pH in horses (Cuddeford 1994). In rats, Fisher et al (1990) have shown that hypercalcemia affects basal and histamine-stimulated acid secretion differently, depending on the amount of dietary calcium. In general the buffering effect is not likely due to intragastric pH neutralization but rather due to a higher calcium influx into cells that are involved in gastric acid secretion (parietal, mast, and gastrin G cells).…”

Section: Figmentioning

confidence: 99%

“…In general the buffering effect is not likely due to intragastric pH neutralization but rather due to a higher calcium influx into cells that are involved in gastric acid secretion (parietal, mast, and gastrin G cells). In the parietal cells, for example, calcium is able to reduce cAMP levels and thereby inhibit acid secretion (Fisher et al 1990). In addition hydrogen chloride (HCl) decreases the cellular sodium transport in the equine stomach.…”

Section: Figmentioning

confidence: 99%

Effects of feeding alfalfa hay in comparison to meadow hay on the gastric mucosa in adult Warmblood horses

Bäuerlein¹,

Sabban²,

Venner³

et al. 2020

PHK

View full text Add to dashboard Cite

Effects of feeding alfalfa hay in comparison to meadow hay on the gastric mucosa in adult Warmblood horses V. Bäuerlein et al. Pferdeheilkunde -Equine MedicineSummary: Equine gastric ulcer syndrome (EGUS) is a common health problem in horses and foals. Beside the importance of forage feeding for the gastric mucosa, results of studies targeting the specific effect of alfalfa on different gastric mucosal regions are controversial. The objectives of this study were to determine the influence of the two forage types (1) meadow hay and (2) alfalfa hay with similar fiber length on different gastric mucosal regions in order to further clarify the effect of alfalfa hay on the equine gastric mucosa. It was hypothesized that feeding alfalfa hay will impair mucosal integrity of the pylorus and antrum pyloricum but may be a benefit for the squamous regions. In a randomized blinded prospective study with a cross-over design, 10 healthy adult warmblood horses were separated randomly into two groups each with five horses. Both groups were fed with 2 kg/100 kg BW/animal/day alfalfa hay or meadow hay in two feeding periods each 21 days long. A wash out period of 21 days was conducted between the feeding periods. Before and after feeding periods body condition score (BCS), body weight (BW), clinical health status, feces pH and particle size and gastroscopic findings were determined. Each region of the gastric mucosa was assessed and scored separately. Data such as BW, fecal pH and fecal particle size were analyzed for normal distribution by the Shapiro-Wilks test. BCS, gastroscopic findings and fecal pH were subjected to non-parametric statistical tests. Kruskal-Wallis ANOVA and Wilcoxon test were performed to compare the findings in gastric mucosal scores, BCS and fecal pH. The relative change in BW and fecal particle size were analyzed by one-factorial analysis of variance (ANOVA). Data are presented as medians, 25th and 75th percentiles. Relative BW changes and fecal particle size are given as means ± standard deviation (SD). Statistical significance was set at p < 0.05. Before starting the feeding trial, the prevalence of overall gastric mucosal lesions was 100 % with a median severity score of 1. After the feeding period, the median lesion score of the lesser curvature of the squamous region decreased significantly from a median of 1 to a median of 0 in the alfalfa group. The median score of 0 remained constant before and after feeding the meadow hay. Findings in the pyloric region did not differ significantly between the two feeding groups. We concluded that feeding alfalfa hay seems to have no detrimental effects on the mucosal integrity at the squamous gastric region in healthy adult horses. With respect to the glandular area, feeding alfalfa hay appears to be noncritical in healthy adult horses. Further studies are needed to investigate the effects of feeding alfalfa hay in horses suffering from severe mucosal lesions at the antrum pyloricum or pylorus. Furthermore, the longer fecal particle size in horses fed alfalfa hay...

show abstract

Inhibition of gastric acid secretion in the rat by high calcium

Cited by 9 publications

References 28 publications

Effects of alfalfa chaff on the gastric mucosa in adult horses

Effects of alfalfa chaff on the gastric mucosa in adult horses

The impact of feeding a high-fibre and high-fat concentrated diet on the recovery of horses suffering from gastric ulcers

Effects of feeding alfalfa hay in comparison to meadow hay on the gastric mucosa in adult Warmblood horses

Contact Info

Product

Resources

About