Inhibition of gastric emptying and drug absorption by narcotic analgesics.

Abstract

The effect of intramuscular pethidine or diamorphine on gastric emptying and the absorption of orally administered paracetamol was assessed in eight normal subjects. 2 Both drugs produced a significant and striking delay in gastric emptying and absorption of paracetamol. 3 It seems inevitable that pethidine and diamorphine will retard the absorption of other orally administered drugs.

Comparison of the effect of cisapride and metoclopramide on morphine‐ induced delay in gastric emptying.

“…Gastric emptying after premedication was measured using the rate of absorption of orally administered paracetamol (Nimmo et al, 1975b). Paracetamol 1.5 g (3 Panadol tablets) was taken with water 50 ml, 20 min after the premedication.…”

Impaired absorption of paracetamol in vegetarians.

“…It is normally rapidly and completely absorbed from the upper small intestine and the rate is determined by factors such as formulation [1][2][3] and gastric emptying [4,5]. Paracetamol has been used as a model for studies of drug absorption and its absorption has also been used as a non-invasive measure of the gastric emptying rate [6,7]. Diet and nutritional state are known to influence the metabolism of many drugs [8], but no important changes have been reported in the case of paracetamol [9][10][11].…”

The effect of phentolamine on basal and pethidine‐induced inhibition of gastric emptying in healthy volunteers.

“…It is well established that acute administration (i.v., i.m.) of opioids results in an immediate delay in gastric emptying as measured by paracetamol absorption rate (Nimmo et al, 1975;Bueno & Fioramonti, 1988). Slattery et al, 1986).…”