Inhibition of gastric emptying and secretion by pirenzepine and atropine in rats

Scarpignato, Carmelo; Girone, Maria Grazia; Tirelli, F.; Bertaccini, G.

doi:10.1016/0014-2999(84)90156-0

Cited by 20 publications

(11 citation statements)

References 12 publications

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“…However, in these studies, equiactive doses of the compounds were never employed. Since the duration of the antisecretory action is dose-related (Scarpignato et al, 1984;Smith, 1985), the use of non-equiactive doses may lead to erroneous conclusions. In the present study, we compared the respective ED5, values of both antagonists, so that the observed duration of action would have been independent of their potency.…”

Section: Evaluation Of Antiulcer Activitymentioning

confidence: 99%

“…Acid secretion was measured in pylorus-ligated rats as described previously (Scarpignato et al, 1984). Since vagal stimulation following pylorus ligation in the rat causes mobilization of histamine (Code, 1982), this model appears to be suitable for the evaluation of antisecretory properties of H2-receptor antagonists and has been successfully employed in our laboratory to study new compounds of this type (Scarpignato et al, 1986 Gastric emptying was measured by a method previously described and validated (Scarpignato, 1983;Scarpignato et al, 1984;.…”

Section: Measurement Of Gastric Secretionmentioning

confidence: 99%

“…Since vagal stimulation following pylorus ligation in the rat causes mobilization of histamine (Code, 1982), this model appears to be suitable for the evaluation of antisecretory properties of H2-receptor antagonists and has been successfully employed in our laboratory to study new compounds of this type (Scarpignato et al, 1986 Gastric emptying was measured by a method previously described and validated (Scarpignato, 1983;Scarpignato et al, 1984;. The test meal consisted of 1.5 ml per rat of a prewarmed (350C) solution of phenol red (50mg dissolved in 100 ml of aqueous methylcellulose; 1.5% w/v).…”

Section: Measurement Of Gastric Secretionmentioning

confidence: 99%

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Antisecretory and antiulcer effect of the H₂‐receptor antagonist famotidine in the rat: comparison with ranitidine

Scarpignato

Tramacere

Zappia

1987

British J Pharmacology

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1 The effects of the new H2-receptor antagonist famotidine, administered orally, on gastric secretion and emptying as well as on experimentally-induced gastric and duodenal ulcers were studied in the rat. Ranitidine was used as a reference compound.2 Both compounds inhibited acid secretion in a dose-dependent manner. Calculated ED_, values were 0.80 and 6.84mg kg' for famotidine and ranitidine, respectively. However, the duration of the antisecretory action was the same for both drugs. 3 The effect of the two drugs, administered at equiactive antisecretory doses, on gastric emptying was different. Ranitidine significantly accelerated the emptying rate whereas famotidine had no effect. 4 Famotidine reduced, in a dose-dependent manner, ulcer incidence in stomachs of dimaprit-treated rats and in duodena of cysteamine-treated animals with a potency respectively 2 and 7 times higher than that of ranitidine. 5 Famotidine is therefore an effective antisecretory and untiulcer'compound. Its potency, but not its efficacy, is higher than that of ranitidine. Moreover, the duration of the antisecretory action is virtually the same for both drugs.

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Section: Evaluation Of Antiulcer Activitymentioning

confidence: 99%

Section: Measurement Of Gastric Secretionmentioning

confidence: 99%

Section: Measurement Of Gastric Secretionmentioning

confidence: 99%

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Antisecretory and antiulcer effect of the H₂‐receptor antagonist famotidine in the rat: comparison with ranitidine

Scarpignato

Tramacere

Zappia

1987

British J Pharmacology

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“…1 or 2 mg/kg) or hexa méthonium (Koch-Light; 5 or 10 mg/kg) were dis solved in a 0.9% w/v NaCI solution (saline) and injected either intraperitoneally (atropine) or subcu taneously (pircnzepine and hexaméthonium) 30 min before ethanol (BDH) administration (either 50 or 80% v/v, given orally in a volume of 10 ml/kg). Experimental evidence has indicated that the two drugs show similar pharmacological actions when given by either route of administration [4,5]. The rats were killed by sharp blow on the head 1 h after etha nol ingestion, and their stomachs were removed.…”

Section: Drug Administration and Lesion Determinationmentioning

confidence: 99%

Cholinoceptor Blockers Protect against Ethanol-Induced Gastric Mucosal Damage in Rats

Cho

Ogle²

1991

Pharmacology

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The role of the cholinergic nervous system in ethanol-induced gastric mucosal damage has been examined in rats. Oral administration of 50 or 80% ethanol produced haemorrhagic lesions which were reduced by atropine pretreatment (0.65, 2.5, 5 or 10 mg/kg injected i.p.); there was lesser protection against the higher dose of ethanol. Pirenzepine (a specific M₁ receptor antagonist) pretreatment (0.1, 0.2, 1 or 2 mg/kg, injected s.c.) produced a similar anti-ulcer effect. Hexamethonium administration (5 or 10 mg/kg, injected s.c.) also protected against ethanol-induced gastric injury to a similar extent; it also increased the amount of adherent mucus on the glandular mucosa. This action may, therefore, account for the protective action of the ganglion blocker. It is concluded that ethanol may stimulate the stomach wall ganglionic nicotinic receptors to activate the postganglionic fibres and subsequently the muscarinic receptors which would then trigger off some of the ulcerogenic mechanisms in the stomach. However, ethanol could also produce gastric damage via the non-cholinergic mechanisms; this action becomes more prominent in gastric injury produced by high doses of ethanol.

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“…The Shay method [17], with minor modifications [16], was used for measurement of gastric secretion. Acid hypersecretion following pyloric ligation is me diated predominantly by activation of vagovagal re flexes [12].…”

Section: Measurement O F Gastric Secretionmentioning

confidence: 99%

Inhibition of Gastric Acid Secretion by Adenosine Receptor Stimulation in the Rat

et al. 1987

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The effects of adenosine and its metabolically stable derivative L-phenylisopropyladenosine (L-PIA), acting mainly on A₁ receptors, on gastric acid secretion were studied in the rat. Although inactive by intraduodenal route, subcutaneous adenosine significantly inhibited acid secretion. This inhibition, however, was not dose-dependent. On the contrary, L-PIA was able to decrease dose-dependently acid output by both subcutaneous and intraduodenal route, its ED₅₀ being 0.11 mg/kg subcutaneously and 0.24 mg/kg intraduodenally. The inhibitory effect of L-PIA was reduced by prior administration of theophylline. These results suggest that activation of A₁-receptors inhibits acid secretion in the rat.

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Inhibition of gastric emptying and secretion by pirenzepine and atropine in rats

Cited by 20 publications

References 12 publications

Antisecretory and antiulcer effect of the H₂‐receptor antagonist famotidine in the rat: comparison with ranitidine

Antisecretory and antiulcer effect of the H₂‐receptor antagonist famotidine in the rat: comparison with ranitidine

Cholinoceptor Blockers Protect against Ethanol-Induced Gastric Mucosal Damage in Rats

Inhibition of Gastric Acid Secretion by Adenosine Receptor Stimulation in the Rat

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Inhibition of gastric emptying and secretion by pirenzepine and atropine in rats

Cited by 20 publications

References 12 publications

Antisecretory and antiulcer effect of the H2‐receptor antagonist famotidine in the rat: comparison with ranitidine

Antisecretory and antiulcer effect of the H2‐receptor antagonist famotidine in the rat: comparison with ranitidine

Cholinoceptor Blockers Protect against Ethanol-Induced Gastric Mucosal Damage in Rats

Inhibition of Gastric Acid Secretion by Adenosine Receptor Stimulation in the Rat

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Product

Resources

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Antisecretory and antiulcer effect of the H₂‐receptor antagonist famotidine in the rat: comparison with ranitidine

Antisecretory and antiulcer effect of the H₂‐receptor antagonist famotidine in the rat: comparison with ranitidine